Fig. 6.1 Barbituric acid ring (Reprinted with permission, Cleveland Clinic Center for Medical Art & Photography © 2016. All Rights Reserved) Table 6.1 Structure activity relationship Substitution Effect Position 5 Aryl…
Opioid receptors Receptor Site of analgesic action Action Mu1 Supraspinal Analgesia, euphoria, confusion, and nausea Mu2 Spinal analgesia and supraspinal (brain stem) actions Respiratory depression, cardiovascular (bradycardia) and gastrointestinal effects…
Fig. 14.1 Illustration of the coagulation cascade with its intrinsic (contact activation) and extrinsic (tissue factor) pathway. Each pathway generates a series of reactions in which inactive circulating enzymes and their…
© Springer International Publishing AG 2018Ehab Farag, Maged Argalious, John E. Tetzlaff and Deepak Sharma (eds.)Basic Sciences in Anesthesiahttps://doi.org/10.1007/978-3-319-62067-1_31 31. Special Problems in Anesthesia John E. Tetzlaff1 (1) Cleveland Clinic Lerner College of Medicine of Case Western Reserve University,…
Fig. 30.1 Different places of action of analgesics used in the perioperative period 30.2.4 Autonomic Contributions to Pain; Visceral Pain Perception and Transmis sion A significant interaction exists between the autonomic nervous…
Score Respiration Able to take deep breath and cough 2 Dyspnea / shallow breathing 1 Apnea 0 O 2 saturation Maintains SpO2 > 92% on room air 2 Needs…
Affected systems Symptoms and signs Skin Generalized hives, itching or flushing, swollen lips, tongue, and uvula, periorbital edema, and conjunctival swelling Respiratory Nasal discharge and congestion, change in voice quality,…
© Springer International Publishing AG 2018Ehab Farag, Maged Argalious, John E. Tetzlaff and Deepak Sharma (eds.)Basic Sciences in Anesthesiahttps://doi.org/10.1007/978-3-319-62067-1_27 27. Blood Products Transfusion Jacek B. Cywinski1 (1) Department of General Anesthesiology, Cleveland Clinic, Cleveland, OH, USA Jacek B. Cywinski…
© Springer International Publishing AG 2018Ehab Farag, Maged Argalious, John E. Tetzlaff and Deepak Sharma (eds.)Basic Sciences in Anesthesiahttps://doi.org/10.1007/978-3-319-62067-1_25 25. Premedication Kenneth C. CummingsIII1 (1) Department of General Anesthesiology, Cleveland Clinic, Cleveland, OH, USA Kenneth C. CummingsIII Email: cummink2@ccf.org…
Anesthetic Effect of decreased metabolism on duration of action Propofol No effect Etomidate No effect Morphine Prolonged Succinylcholine Prolonged Fentanyl No effect Midazolam Prolonged Vecuronium Prolonged Rocuronium Prolonged Water-soluble drugs,…
