Fig. 6.1 12-Lead Electrocardiogram obtained at time of patients presentation Question How would you proceed in the management of this patient? Answer This patient now exhibits EKG findings that are…
(25.1) where concentration is C, t is time after the dose, A is the concentration at time 0 for the distribution rate represented by the broken line graph with the…
Fig. 11.1 Compartmental model for propofol using the Eleveld PK model for a 70-kg, 35-year-old male patient The three compartments in the above PK model represent the volumes for the…
Fig. 10.1 Time course of plasma propofol concentrations arising from three different dosing schemes. All three time courses show the predicted plasma concentration of propofol administered at 8 mg/kg/h for 60 min…
Fig. 23.1 a Propofol TCI set at 3 μg/ml, b MCI propofol infusion regimen, designed to give a plasma concentration of 3 μg/ml: 1 mg/kg bolus, 10 mg/kg/h, reduced to 8 mg/kg/h at 10 min, reduced…
2. Adjusted body weight (kg) [28]: Was derived to scale doses in the obese. It uses the ideal weight (IBW) and to a varying degree the amount of weight…
Fig. 8.1 The volume of distribution accounts for the dilution of drug when it is first injected into the body Fig. 8.2 Clearance is the flow of blood or plasma…
Bedford and Leeds recommendations Recent considerations • Careful risk-benefit analysis for surgery on elderly patients • Frailty assessment • Consideration of the risk of postoperative cognitive dysfunction • No routine…
Minimal sedation Moderate sedation Deep sedation General anaesthesia Responsiveness Normal response to verbal stimulation Purposeful response to verbal or tactile stimulation Purposeful response following repeated or painful stimulation Unrousable…
Drugs Species Elimination half-life Volume of distribution Total systemic clearance Comments References Propofol Dogs 322 min 6.5 L/kg 50.1 mg/kg/min No premed, no co-infusion Beagle dogs [5]a 486.2 min 3.38 L/kg 34.4 mg/kg/min Premedication medetomidine 10 μg/kg,…
