Anesthetic Effect of decreased metabolism on duration of action Propofol No effect Etomidate No effect Morphine Prolonged Succinylcholine Prolonged Fentanyl No effect Midazolam Prolonged Vecuronium Prolonged Rocuronium Prolonged Water-soluble drugs,…
Organ system SNS response SNS receptor PSNS response PSNS receptor Eye Iris radial Dilation α(alpha)1 Iris ciliary Relaxation β(beta)2 Miosis (contraction) M3 Circular Accommodation (contraction) M3 Heart Rate of contraction…
Fig. 10.1 Molecular structure of inhalational anesthetics Table 10.1 Physical and chemical properties of inhaled anesthetics Nitrous Oxide Halothane Methoxyflurane Enflurane Isoflurane Desflurane Sevoflurane Molecular weight 44 197 165 184 184…
By blocking the carbonic anhydrase, these inhibitors decrease the reabsorption of NaHCO3 by 25–30% and cause diuresis. They have a weak natriuretic effect due to compensatory mechanisms that come into…
© Springer International Publishing AG 2018Ehab Farag, Maged Argalious, John E. Tetzlaff and Deepak Sharma (eds.)Basic Sciences in Anesthesiahttps://doi.org/10.1007/978-3-319-62067-1_11 11. Cardiovascular Anatomy and Pharmacology Maria Bauer1 (1) Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Hospital,…
© Springer International Publishing AG 2018Ehab Farag, Maged Argalious, John E. Tetzlaff and Deepak Sharma (eds.)Basic Sciences in Anesthesiahttps://doi.org/10.1007/978-3-319-62067-1_12 12. Respiratory Pharmacology Ahmad Maher Adi1 (1) Department of Cardiothoracic Anesthesiology and Critical Care, Cleveland Clinic, Cleveland, OH, USA …
Mu receptor Kappa receptor Delta receptor Molecular details and endogenous agonists 7- transmembrane domain G-protein Enkephalins (high affinity) Beta endorphin (high affinity) Dynorphins (low affinity) Subtypes: μ(mu) 1, 2…
The following items may suggest a possible haemostatic disorder No Yes Situation never encountered 1. Have you previously consulted a doctor or received a treatment for prolonged or unusual bleeding,…
Agent (drug) Availability Cost Purity/potency Mode of administration Chewing (absorption via oral mucous membranes) Gastrointestinal Intranasal Subcutaneous and intramuscular Intravenous Inhalation Speed of onset and termination of effects (pharmacokinetics: combination…
Class BMI (kg/m2) Underweight <20.0 Normal range 20.0–24.9 Obese class 1 25.0–29.9 Obese class 2 30.0–34.9 Obese class 3 35.0–39.9 Obese class 4 40.0–49.9 Obese class 5 50.0–59.9 Obese class…
