Clinical Cases
Fig. 14.1 ROTEM thromboelastometry profile performed before, during, and after the surgical intervention and then daily for 1 week. Reference values: INTEM CT 100–240 s, CFT 30–110 s, MCF 50–72…
Blood Products, Derivates, and Prohemostatic Drugs
Fig. 6.1 EXTEM ROTEM trace of low platelet count in a patient with cirrhosis pre and post platelet transfusion 6.2.3 Adverse Events A comprehensive review of adverse plasma transfusion reactions…
Clinical Management of Severe Bleeding in Trauma Patients
Fig. 7.1 Physiopathology of trauma-induced coagulopathy Transfusion of ≥10 units of RBCs, which approximates the total blood volume (TBV) of an average adult patient, within 24 h Transfusion of at…
Management of Severe Bleeding in Cardiovascular Patients
Fig. 8.1 Calibrated automated thrombography. ETP endogenous thrombin potential; TF tissue factor Conventional tests offer a limited information on thrombin generation, even if prothrombin time and international normalized ratio are…
Practical Issues in POCT
Fig. 13.1 Emilia-Romagna, Italy Fig. 13.2 Emilia-Romagna integrated trauma care system (SIAT) The SIAT works according to hub and spoke model: severe and resource-consuming patients are centralized in first-level hubs…
Management of Severe Bleeding in Liver Disease and Transplantation
Body weight (kg) Targeted increase in MCF (A10) FIB TEM 4 mm 8 mm 12 mm 16 mm 20 0.5 g 1 g 1.5 g 2 g 40 1 g…
Assessment of the Effects of Antithrombotic Drugs
Fig. 12.1 Heparin rebound. Postoperative bleeding in aortic valve replacement. (a) Kaolin-TEG trace without heparinase. (b) Kaolin-TEG trace with heparinase. The presence of heparinase reduces R-time and K-time and normalizes…
Disorders of Hemostasis in the Bleeding Intensive Care Unit Patient
Fig. 11.1 A schematic overview of the main principal coagulopathies in ICU critical patients. DIC disseminated intravascular coagulopathy, HIT heparin-induced thrombocytopenia, NOAC novel oral anticoagulant (Modified from Levi and van…
Clinical Management of Postpartum Hemorrhage
© Springer International Publishing Switzerland 2016Marco Ranucci and Paolo Simioni (eds.)Point-of-Care Tests for Severe Hemorrhage10.1007/978-3-319-24795-3_9 9. Clinical Management of Postpartum Hemorrhage Vanessa Agostini1 , Maria Pia Rainaldi2, Maria Grazia Frigo3, Massimo Micaglio4 and Agostino Brizzi5 (1) Transfusion Medicine Cesena/Forlì and Blood Establishment, Clinical…
Coagulation and Point of Care in Clinical Practice: History
© Springer International Publishing Switzerland 2016Marco Ranucci and Paolo Simioni (eds.)Point-of-Care Tests for Severe Hemorrhage10.1007/978-3-319-24795-3_5 5. Coagulation and Point of Care in Clinical Practice: History Luca Spiezia1 and Paolo Simioni2 (1) Department of Medicine, University of Padua…
