Clinical Pharmacology of Local Anesthetics
Clinical Pharmacology of Local Anesthetics John F. Butterworth IV A review of the clinical pharmacology of local anesthetics must consider those factors that influence the usefulness and toxicity of the…
Properties, Absorption, and Disposition of Local Anesthetic Agents
Properties, Absorption, and Disposition of Local Anesthetic Agents Laurence E. Mather Geoffrey T. Tucker We dedicate this essay to the memory of our late friends and colleagues who contributed much…
Neural Physiology and Local Anesthetic Action
Neural Physiology and Local Anesthetic Action Gary R. Strichartz Els Pastijn Kenji Sugimoto Basic Physiology and Pharmacology Overview of the Neuron Local anesthetic drugs reversibly block conduction of nerve impulses…
The History of Regional Anesthesia
The History of Regional Anesthesia David L. Brown B. Raymond Fink The popularization of regional anesthesia was not possible until two events occurred. First, a local anesthetic was required, and…
Substance Abuse and Addiction
Substance Abuse and Addiction Arnold J. Berry Jerry S. Matsumura CASE SUMMARY A 36-year-old anesthesiologist was well liked by his anesthesiologist colleagues and was popular with patients. He arrived early…
Chemical Agents and Radiation Exposure
Chemical Agents and Radiation Exposure Paul Barach Ernesto Pretto Jr. CASE SUMMARY The New York City police stage a raid on a suspected terrorist chemical laboratory on the lower west…
Sleep and Fatigue
Sleep and Fatigue Timothy C. Flynn CASE SUMMARY Dr. W is a CA-2 resident in a university anesthesiology residency program. He has had a rough week. One of the other…
Bioterrorism
Bioterrorism Ben Boedeker Christian Popa PART I SMALLPOX CASE SUMMARY A treaty verification monitor toured laboratories in the former Soviet Union where bioweapons were reported to have been made and…
Herbal Remedies and Over-The-Counter Drugs
Herbal Remedies and Over-The-Counter Drugs Miguel Bejar Hernando Desoto CASE SUMMARY A 32-year-old woman presents to the operating room at 9:00 PM for surgical control of oropharyngeal bleeding. She had…
Adverse Drug Interactions
Adverse Drug Interactions Allan P. Klock Jr. CASE SUMMARY A 67-year-old man weighing 84 kg, with a history of urinary incontinence following a radical prostatectomy, is scheduled for insertion of…
