Role of the Endocannabinoid System in Pain

Oct 21, 2016 by in PAIN MEDICINE Comments Off on Role of the Endocannabinoid System in Pain

Fig. 1 Endocannabinoid signalling at a notional neuronal synapse. The major synthetic, signalling, and catabolic pathways for AEA and 2-AG are shown. Other GPCRs may be involved in endocannabinoid signalling…

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Role of Glia in the Spinal Cord in Neuropathic and Inflammatory Pain

Oct 21, 2016 by in PAIN MEDICINE Comments Off on Role of Glia in the Spinal Cord in Neuropathic and Inflammatory Pain

© Springer-Verlag Berlin Heidelberg 2015Hans-Georg Schaible (ed.)Pain ControlHandbook of Experimental Pharmacology22710.1007/978-3-662-46450-2_8 The Role of Glia in the Spinal Cord in Neuropathic and Inflammatory Pain Elizabeth Amy Old1, Anna K. Clark1 and Marzia Malcangio1   (1) Wolfson Centre for Age…

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Concepts of Pain Therapy Based on Neuronal Mechanisms

Oct 21, 2016 by in PAIN MEDICINE Comments Off on Concepts of Pain Therapy Based on Neuronal Mechanisms

Fig. 1 Changes in the nociceptive system during pathophysiologic nociceptive pain and neuropathic pain. Spinal sensitization and increased hyperexcitability at the supraspinal level form the process of central sensitization At…

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