ANESTHETICS
GENERAL PRINCIPLES • Lipophilic drugs produce rapid induction of general anesthesia • Most IV anesthetics exert effect through activation or augmentation of postsynaptic GABAA receptors (↑ chloride influx → hyperpolarization…
Intensive care
Chapter 7 Intensive care Acute Respiratory Distress Syndrome (ARDS) First described in Denver, Colorado, in 1967 by Ashbaugh. North American–European consensus group has changed the definition to ‘acute’ (as opposed…
Pharmacology
CHAPTER 11 Pharmacology Anaesthetic Gases Oxygen Discovered by Joseph Priestley in 1777. Manufactured by: • fractional distillation of liquid air • passing air over an artificial zeolite, which entraps N2,…
Respiratory system
CHAPTER 2 Respiratory system Assessing The Airway During routine anaesthesia, the incidence of difficult tracheal intubation (≥3 attempts at intubation or >10 min to accomplish it) has been estimated as…
Paediatrics
Chapter 9 Paediatrics General Paediatrics Definitions • Neonate – first 28 days of life or <44 weeks post-conception • Infant – 1 month to 1 year • Child – >1…
Cardiovascular system
1 Cardiovascular system Anaesthesia and cardiac disease New York Heart Association classification of cardiovascular disease • I Normal cardiac output. Asymptomatic on heavy exertion • II Normal cardiac output. Symptomatic…
Other systems
Chapter 4 Other systems Dental anaesthesia The first dental GA was given by Cotton and Wells in 1844. Currently, 300 000 dental GAs are given per annum (70% children) and,…
