Novel Targets of Current Analgesic Drug Development

Sep 18, 2016 by in ANESTHESIA Comments Off on Novel Targets of Current Analgesic Drug Development

14. Richardson JD, Aanonsen L, Hargreaves KM. Antihyperalgesic effects of spinal cannabinoids. Eur J Pharmacol. 1998;345:145–53.PubMed 15. Liu C, Walker JM. Effects of a cannabinoid agonist on spinal nociceptive neurons…

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Serotonin Syndrome

Sep 18, 2016 by in ANESTHESIA Comments Off on Serotonin Syndrome

Inhibitors of serotonin reuptake Selective serotonin reuptake inhibitors (SSRIs): fluoxetine, paroxetine, sertraline, citalopram, fluvoxamine Serotonin-norepinephrine reuptake inhibitors (SNRIs): venlafaxine, desvenlafaxine, duloxetine, milnacipran Tricyclic antidepressants (TCAs): amitriptyline, nortriptyline, protriptyline clomipramine, imipramine,…

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Black Box FDA Warnings and Legal Implications

Sep 18, 2016 by in ANESTHESIA Comments Off on Black Box FDA Warnings and Legal Implications

Drug (date of most recent available labeling) Indication Reason for boxed warning Alternatives Antiemetics Droperidol (Inapsine®) 12/2001 Nausea and vomiting; neuroleptic anesthesia Prolonged QT interval, torsades de pointes Ondansetronb, metoclopramide…

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Blood, Blood Products, and Substitutes

Sep 18, 2016 by in ANESTHESIA Comments Off on Blood, Blood Products, and Substitutes

Blood product Indication Dosing Relative contraindication Whole blood Autologous donated units for elective surgery, large volume hemorrhage, neonatal exchange transfusion  Volume overload PRBC Increase oxygen carrying capacity to tissues, exchange…

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Pediatrics

Sep 18, 2016 by in ANESTHESIA Comments Off on Pediatrics

© Springer Science+Business Media New York 2015Alan David Kaye, Adam M. Kaye and Richard D. Urman (eds.)Essentials of Pharmacology for Anesthesia, Pain Medicine, and Critical Care10.1007/978-1-4614-8948-1_42 42. Pediatrics Vanessa Ng1  , Karina Gritsenko1   and Rebecca Lintner1   (1) Department of Anesthesiology,…

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Analgesics: Opiate Agonists, Mixed Agonists/Antagonists, and Antagonists for Acute Pain Management

Sep 18, 2016 by in ANESTHESIA Comments Off on Analgesics: Opiate Agonists, Mixed Agonists/Antagonists, and Antagonists for Acute Pain Management

7.1 Morphine 7.2 Hydromorphone 7.3 Fentanyl 7.4 Butorphanol 7.5 Nalbuphine 7.6 Buprenorphine References 1. Mather LE. Pharmacokinetic and pharmacodynamic profiles of opioid analgesics: a sameness amongst equals? Pain. 1990;43:3–6.PubMedCrossRef 2….

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Nonopioid Analgesic and Adjunct Drugs

Sep 18, 2016 by in ANESTHESIA Comments Off on Nonopioid Analgesic and Adjunct Drugs

Chemical Structure 9.1 Dexamethasone Chemical Structure 9.2 Dexmedetomidine Chemical Structure 9.3 Acetaminophen/paracetamol Chemical Structure 9.4 Ketamine Chemical Structure 9.5 Ketorolac Chemical Structure 9.6 Celecoxib References 1. Cashman JN. The mechanisms…

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Neuromuscular Blockers

Sep 18, 2016 by in ANESTHESIA Comments Off on Neuromuscular Blockers

Percentage blocked receptors T1 (% normal) T4 (% normal) T4/T1 (% normal) Tetanus 100     95      0  T1 lost  90 10  T2 lost   20  T3 lost  80 25 0 T4 lost…

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Enteral and Parenteral Nutrition

Sep 18, 2016 by in ANESTHESIA Comments Off on Enteral and Parenteral Nutrition

© Springer Science+Business Media New York 2015Alan David Kaye, Adam M. Kaye and Richard D. Urman (eds.)Essentials of Pharmacology for Anesthesia, Pain Medicine, and Critical Care10.1007/978-1-4614-8948-1_40 40. Enteral and Parenteral Nutrition Jillian Redgate1   and Sumit Singh2, 1   (1)…

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Hemostatic Agents

Sep 18, 2016 by in ANESTHESIA Comments Off on Hemostatic Agents

  Comments Dose (IV) Frequency FDA approved use Hemophilia A or B with inhibitors rVIIa is first-line therapy 90 mcg/kg Every 2–3 h initially, with subsequent dosing per hematology service…

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