Biochemical and Metabolic Principles

Nov 19, 2019 by in ANESTHESIA Comments Off on Biochemical and Metabolic Principles

INTRODUCTION Print Section Listen Xenobiotics are compounds that are foreign to a living system. Toxic xenobiotics interfere with critical metabolic processes, cause structural damage to cells, or alter cellular genetic…

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Transdermal Toxicology

Nov 19, 2019 by in ANESTHESIA Comments Off on Transdermal Toxicology

HISTORY AND CURRENT USE Print Section Listen Applying a xenobiotic to the skin to treat a systemic medical condition is not new. Ointments and other salves have been applied topically…

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Case Study 3

Nov 19, 2019 by in ANESTHESIA Comments Off on Case Study 3

CASE STUDY 3 Print Section Listen History A 54-year-old man presented to the emergency department (ED) complaining that he was weak, dizzy, and felt as if he was about to…

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Fluid, Electrolyte, and Acid–Base Principles

Nov 19, 2019 by in ANESTHESIA Comments Off on Fluid, Electrolyte, and Acid–Base Principles

INTRODUCTION Print Section Listen A meaningful analysis of fluid, electrolyte, and acid–base abnormalities is dependent on the history and physical examination of each patient. Although a rigorous appraisal of laboratory…

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Chemical Principles

Nov 19, 2019 by in ANESTHESIA Comments Off on Chemical Principles

INTRODUCTION Print Section Listen Chemistry is the science of matter; it encompasses the structure, physical properties, and reactivities of atoms and their compounds. In many respects, toxicology is the science…

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Principles of Diagnostic Imaging

Nov 19, 2019 by in ANESTHESIA Comments Off on Principles of Diagnostic Imaging

INTRODUCTION Print Section Listen Diagnostic imaging plays a significant role in the management of many patients with toxicologic emergencies. Radiography can confirm a diagnosis (eg, by visualizing the xenobiotic), assist…

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Laboratory Principles

Nov 19, 2019 by in ANESTHESIA Comments Off on Laboratory Principles

INTRODUCTION Print Section Listen Clinical toxicology addresses the harm caused by acute and chronic exposures to excessive amounts of a xenobiotic. Detecting the presence or measuring the concentration of toxic…

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Whole-Bowel Irrigation and Other Intestinal Evacuants

Nov 19, 2019 by in ANESTHESIA Comments Off on Whole-Bowel Irrigation and Other Intestinal Evacuants

INTRODUCTION Print Section Listen One approach to altering the pharmacokinetics of a xenobiotic is to administer a gastrointestinal (GI) evacuant. Selected patients benefit from minimizing systemic exposure by decreasing GI…

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Activated Charcoal

Nov 19, 2019 by in ANESTHESIA Comments Off on Activated Charcoal

INTRODUCTION Print Section Listen Activated charcoal (AC) is an excellent nonspecific adsorbent. Conclusions regarding the role of AC in poison management are achieved through the integration of pharmacologic data, controlled…

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