Wegener’s Granulomatosis

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86. Wegener’s Granulomatosis Definition Wegener’s granulomatosis (WG) is the systemic vasculitis of small and medium arteries, venules, and arterioles. Large arteries may also be affected. Incidence WG is rare; the…

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Wilson’s Disease

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88. Wilson’s Disease Definition Wilson’s disease is an autosomal recessive, inherited, rare, progressive disorder in the metabolism of copper, characterized by excessive copper deposits in the brain, liver, and other…

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Sturge-Weber Syndrome

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81. Sturge-Weber Syndrome Definition Sturge-Weber syndrome (SWS) is a congenital disorder characterized by leptomeningeal angiomas as well as cutaneous angiomas along distributions of the trigeminal nerve (usually only on one…

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Stevens-Johnson Syndrome

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80. Stevens-Johnson Syndrome Definition Stevens-Johnson syndrome (SJS) is a hypersensitivity disorder mediated by immune-complex formation. It is a potentially fatal systemic disorder that is a severe type of erythema multiforme….

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Sjögren Syndrome

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79. Sjögren Syndrome Definition Sjögren syndrome is a complex disorder in which exocrine organs are infiltrated by lymphocytes. It is characterized by sicca symptoms and is frequently associated with systemic…

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Pyelonephritis

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74. Pyelonephritis Definition Pyelonephritis is a potentially organ-threatening, fatal inflammation of the kidney and renal pelvis secondary to a bacterial infection that begins in the interstitial tissues and rapidly extends…

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Sarcoidosis

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76. Sarcoidosis Definition Sarcoidosis is a chronic multisystem inflammatory disease characterized by noncaseating granulomas as well as lymphocytic alveolitis. Incidence In the United States the overall incidence of sarcoidosis ranges…

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Scleroderma

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77. Scleroderma Definition “Scleroderma” literally means “hard or thickened skin.” The disease is a multisystem disorder characterized by inflammation, tissue fibrosis, and microvascular occlusion as the result of excessive production…

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Portal Hypertension

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70. Portal Hypertension Definition Portal hypertension is the presence within the portal circulation of a pressure gradient of 12 mm Hg or higher. This malady is associated with numerous conditions…

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Paget’s Disease of the Bone

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67. Paget’s Disease of the Bone Definition Paget’s disease of the bone is a relatively common disease of middle-aged and elderly people in which there is excessive and abnormal bone…

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