Patient Blood Management: Transfusion Therapy

Mar 7, 2020 by in ANESTHESIA Comments Off on Patient Blood Management: Transfusion Therapy

Key Points ▪ Blood transfusion is safer now than at any other time in history. Advances in donor screening, improved testing, automated data systems, and changes in transfusion medicine practices…

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Basic Principles of Pharmacology

Mar 7, 2020 by in ANESTHESIA Comments Off on Basic Principles of Pharmacology

Key Wordsage, body habitus, clearance, interactions, patient characteristics, pharmacodynamics, pharmacokinetics, volumes of distribution   Key Points ▪ Pharmacokinetics describes the relationship between drug dose and drug concentration in plasma or…

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Management of the Patient with Chronic Pain

Mar 7, 2020 by in ANESTHESIA Comments Off on Management of the Patient with Chronic Pain

Key Points ▪ The normal physiology of neuronal function, receptors, and ion channels is altered by persistent pain. ▪ Because of the large number of sources and manifestation of chronic…

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Opioids

Mar 7, 2020 by in ANESTHESIA Comments Off on Opioids

Key WordsAnalgesia, Biased Agonism, Delta-, Dependence, Hyperalgesia, Kappa- Receptor, Metabolism, Mu-, Pharmacodynamics, Pharmacokinetics, Tolerance   Key Points ▪ Opioids are a vital part of providing the analgesic component of anesthesia…

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Anesthetic Implications of Concurrent Diseases

Mar 7, 2020 by in ANESTHESIA Comments Off on Anesthetic Implications of Concurrent Diseases

Key Points ▪ The history and physical examination most accurately predict the risks of anesthesia and the likelihood of required changes in monitoring or therapy. ▪ For diabetic patients, end-organ…

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Neuromuscular Disorders Including Malignant Hyperthermia and Other Genetic Disorders

Mar 7, 2020 by in ANESTHESIA Comments Off on Neuromuscular Disorders Including Malignant Hyperthermia and Other Genetic Disorders

Key WordsCharcot-Marie-Tooth Disease, Dantrolene, Guillain-Barre Syndrome, Malignant Hyperthermia, Multiple Sclerosis, Muscular Dystrophy, Ryanodine   Key Points ▪ Malignant hyperthermia (MH) is a pharmacogenetic disorder inherited primarily in an autosomal dominant…

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Intravenous Anesthetics

Mar 7, 2020 by in ANESTHESIA Comments Off on Intravenous Anesthetics

Key Points ▪ The introduction of thiopental into clinical practice in 1934 marked the beginning of modern intravenous (IV) anesthesia. Today, IV anesthetics are used for induction and maintenance of…

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Pharmacology of Neuromuscular Blocking Drugs

Mar 7, 2020 by in ANESTHESIA Comments Off on Pharmacology of Neuromuscular Blocking Drugs

Key Points ▪ Two different populations of nicotinic acetylcholine receptors exist at the mammalian neuromuscular junction. In the adult, the nicotinic acetylcholine receptor at the postsynaptic (muscular) membrane is composed…

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