Sepsis and Systemic Inflammatory Syndromes

Sep 27, 2026 by in CRITICAL CARE Comments Off on Sepsis and Systemic Inflammatory Syndromes
Systemic inflammation induced brain dysfunction is a frequent, yet underrecognized, complication of sepsis. It is driven by systemic–brain immune crosstalk, blood–brain barrier dysfunction, glial activation, and synaptic injury, and is…
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Immunosuppression in the Pathophysiology of Sepsis

Sep 27, 2026 by in CRITICAL CARE Comments Off on Immunosuppression in the Pathophysiology of Sepsis
Sepsis-induced immunosuppression contributes to mortality, increased susceptibility to secondary infections and long-term complications. Myeloid cells undergo functional reprogramming, while adaptive immune cells, particularly T lymphocytes, show altered composition and lymphopenia….
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The Immunometabolic Architecture of Sepsis

Sep 27, 2026 by in CRITICAL CARE Comments Off on The Immunometabolic Architecture of Sepsis
Sepsis continues to be a leading public health challenge, accounting for almost 20% of annual global deaths. Here, we review the evolving pathophysiological understanding of this syndrome by highlighting the…
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Sepsis and the Immunocompromised Host

Sep 27, 2026 by in CRITICAL CARE Comments Off on Sepsis and the Immunocompromised Host
The immunocompromised host represents a growing and heterogeneous population within the intensive care unit. Advances in oncologic therapies, organ transplantation, and immunomodulatory treatments for autoimmune diseases have expanded survival but…
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The Nonimmune Aspects of Sepsis

Sep 27, 2026 by in CRITICAL CARE Comments Off on The Nonimmune Aspects of Sepsis
This article highlights the most important nonimmune pathways in sepsis, with a focus on adaptive versus maladaptive mechanisms. Understanding of maladaptive mechanisms has high potential to enhance clinical care of…
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Post-Sepsis Syndrome

Sep 27, 2026 by in CRITICAL CARE Comments Off on Post-Sepsis Syndrome
Sepsis survivorship is increasing, but many survivors develop post-sepsis syndrome, marked by high early readmission rates and new-onset conditions, notably recurrent infections, cardiovascular, psychiatric, and kidney disease. Persistent physical, cognitive,…
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Early Management of Sepsis

Sep 27, 2026 by in CRITICAL CARE Comments Off on Early Management of Sepsis
Prompt recognition and appropriate early management of sepsis reduces mortality. There are 2 major goals of early sepsis management, which should be pursued urgently and in parallel—(1) infection control and…
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