Chemical Structure 23.1 Amphetamine (Adderall) Chemical Structure 23.2 Modafinil (Provigil) Chemical Structure 23.3 Armodafinil (Nuvigil) Chemical Structure 23.4 Caffeine Chemical Structure 23.5 Methylphenidate (Ritalin) Chemical Structure 23.6 Atomoxetine (Strattera) HCl…
Fig. 31.1 Four phases of cell division (Source: Brunton et al. [3]. Copyright © McGraw Hill Companies, Inc) Antimetabolites (S-Phase) Antimetabolite drugs are also referred to as nucleic acid synthesis…
Because the AT-III level recovery varies, thus 20 min after infusion of initial dose, recheck AT-III level and recalculate the additional dose necessary to correct AT-III deficiency. Then it is…
Glycopyrrolate Heparin Insulin Nondepolarizing neuromuscular blocker Succinylcholine This chapter will also discuss many pharmacologic therapies for the pregnant patient. Local anesthetics and opioids are the foundation of most neuraxial techniques…
Class Generic (trade) names Common side effects and special points SSRIs Citalopram (Celexa, Cipram, Cipramil, Serostat) SSRIs are safer when overdosed Escitalopram (Lexapro) GI: nausea, diarrhea, headache Fluvoxamine (Dumirox, Faverin,…
Group 1 Group 2 Group 3 Agents Etomidate, propofol Ketamine, nitrous oxide, xenon, cyclopropane Barbiturates, halo alkyls Actions Potent hypnotics Potent analgesics Potent hypnotics Weak immobilizers Weak hypnotics Potent…
Drug Protein binding and hepatic extraction ratio Volume of distribution at steady state Clearance Elimination half-life Clinical significance in patients with liver disease Thiopental 85 % 0.2 Increased Decreased Prolonged…
Drug Mechanism Indication Dosing options Drug interactions Side effects Monobactam (aztreonam) Inhibition of cell wall mucopeptide synthesis Strong activity against gram-negative bacteria; may be substituted for penicillins or cephalosporin IV,…
Fig. 46.1 Characteristic short-long-short on ECG rhythm strip preceding episode of torsades de pointes (With kind permission from Springer Science + Business Media: Benson et al. [66], Figure 3, and…
Fig. 54.1 Anesthesia has both desirable and undesirable end points. General anesthetics cause the therapeutic end points of amnesia, immobility, unconsciousness, and analgesia (shown in blue). Cardiovascular instability, convulsions, respiratory…
