The Respiratory Triple Pandemic in the Intensive Care Unit

Sep 27, 2026 by in CRITICAL CARE Comments Off on The Respiratory Triple Pandemic in the Intensive Care Unit
The anticipated “tripledemic” during the 2023–2024 season—in which simultaneous epidemics of SARS‑CoV‑2, influenza, and respiratory syncytial virus were projected—ultimately fell short of early forecasts. Nevertheless, each virus remains a significant…
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Antibiotic Stewardship for the Intensivist

Sep 27, 2026 by in CRITICAL CARE Comments Off on Antibiotic Stewardship for the Intensivist
Intensive care units (ICUs) care for the most severely ill patients and consequently account for the largest volume of antibiotic use in the hospital. Critically ill patients must receive optimal,…
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Recognizing and Managing Hemophagocytic Lymphohistiocytosis in Adults in the Intensive Care Unit

Sep 27, 2026 by in CRITICAL CARE Comments Off on Recognizing and Managing Hemophagocytic Lymphohistiocytosis in Adults in the Intensive Care Unit
Hemophagocytic lymphohistiocytosis is a life-threatening hyperinflammatory syndrome increasingly recognized across age groups. This syndrome is driven by pathologic interferon-γ production, which leads to a self-sustaining positive feedback loop resulting in…
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The Global Intensive Care Unit

Sep 27, 2026 by in CRITICAL CARE Comments Off on The Global Intensive Care Unit
More than 80% of the world’s population lives in low-income and middle-income countries, yet access to critical care remains limited in these regions. Infectious diseases, especially human immunodeficiency virus, tuberculosis,…
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Sepsis and Systemic Inflammatory Syndromes

Sep 27, 2026 by in CRITICAL CARE Comments Off on Sepsis and Systemic Inflammatory Syndromes
Systemic inflammation induced brain dysfunction is a frequent, yet underrecognized, complication of sepsis. It is driven by systemic–brain immune crosstalk, blood–brain barrier dysfunction, glial activation, and synaptic injury, and is…
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