Anesthesia Key

Abstract Pain is defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage. Since pain is so highly subjective, it may also be described as…

Abstract Pharmacokinetics is the study of the way in which the body handles administered drugs. The use of mathematical models allows us to predict how plasma concentration changes with time…

Abstract Structure–activity relationships (SAR) describe how the structure of related drugs influences their behaviour, for example whether they are agonists or antagonists. In order to understand how differences in drug…

Abstract In the previous chapter we explored the mathematical principles and models that can be used to predict plasma concentrations of drugs, particularly compartment models. This chapter will discuss the…

Abstract Interactions occur when one drug modifies the action of another. This interaction may either increase or decrease the second drug’s action. Sometimes these interactions result in unwanted effects, but…

Abstract Isomerism is the phenomenon by which molecules with the same atomic formulae have different structural arrangements – the component atoms of the molecule are the same, but they are…

Abstract Drugs may act in a number of ways to exert their effect. These range from relatively simple non-specific actions that depend on the physicochemical properties of a drug to…

Abstract Drugs may be given by a variety of routes; the route chosen depends on the desired site of action and the type of drug preparations available. Routes used commonly…

Abstract Many drugs need to pass through one or more cell membranes to reach their site of action. A common feature of all cell membranes is a phospholipid bilayer, about…