PAIN MEDICINE

Toxicology Screening for Opioids

Oct 21, 2016 by in PAIN MEDICINE Comments Off on Toxicology Screening for Opioids

Fig. 15.1 In the top row, the three schematics for gas chromatography show that samples containing morphine, hydrocodone, and a combination of the two can be distinguished from one another…

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Clinical Use of Opioids

Oct 21, 2016 by in PAIN MEDICINE Comments Off on Clinical Use of Opioids

Fig. 10.1 Intracellular opioid actions (With permission from Trescot et al. [5]) Fig. 10.2 Opioid receptors, pre- and postsynaptic (With permission from Trescot et al. [5]) The dopaminergic system in…

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Role of Cannabinoids in Pain Management

Oct 21, 2016 by in PAIN MEDICINE Comments Off on Role of Cannabinoids in Pain Management

Fig. 18.1 Putative mechanism of endocannabinoid-mediated retrograde signaling in the nervous system. Activation of metabotropic glutamate receptors (mGluR) by glutamate triggers the activation of the phospholipase C (PLC)-diacylglycerol lipase (DGL)…

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Methadone for Chronic Pain

Oct 21, 2016 by in PAIN MEDICINE Comments Off on Methadone for Chronic Pain

Fig. 14.1 Molecular structure of methadone Methadone‚Äôs activity at opioid sub-receptors is unique. Like morphine, methadone has agonist affinity for both the mu and delta opioid receptors. However, in animal…

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The Future of Pain Pharmacotherapy

Oct 21, 2016 by in PAIN MEDICINE Comments Off on The Future of Pain Pharmacotherapy

Fig. 19.1 A hypothetical graph of the number of available drugs as a function of time. The scales on the abscissa and ordinate are deliberately not specified (See text for…

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Pharmacogenomics of Pain Management

Oct 21, 2016 by in PAIN MEDICINE Comments Off on Pharmacogenomics of Pain Management

Fig. 2.1 Framework of genetic background influencing the response to analgesic drugs The second, more traditional, and better established component of pain related genomics is called pharmacogenomics of pain management…

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