Pharmacodynamic Drug Interactions
Abstract Modern balanced anesthesia consists of the use of a number of drugs to achieve the desired clinical endpoints, such as no awareness, no movement, muscle relaxation, control of blood…
Physiology and Pharmacology of Obesity, Pediatrics, and the Elderly
Abstract Anesthesiologists are frequently asked to care for patients at the extremes of age and size. These patient groups have unique features that require special consideration when formulating an anesthetic…
Pharmacokinetic and Pharmacodynamic Principles for Intravenous Anesthetics
Abstract This chapter presents a review of modern pharmacokinetic and pharmacodynamic concepts that comprise the scientific foundation of rational drug selection and administration of intravenous anesthetics. Keywords intravenous anesthetics, pharmacokinetics,…
Mechanisms of Drug Action
Abstract Understanding the basic principles of pharmacology is fundamental to the practice of medicine in general, but it is perhaps most relevant to the practice of anesthesiology. It is now…
Drug Metabolism and Pharmacogenetics
Abstract Biotransformation is an ancient and vital process that governs a drug’s pharmacokinetics and pharmacodynamics. The enzymes and transporters that control each step in the metabolic pathway are highly polymorphic….
