Genetics of Migraine
Genetics of Migraine Michel D. Ferrari Joost Haan Aarno Palotie Anyone can experience an occasional migraine attack without necessarily being a migraine patient. Not the attack itself, but the repeated…
5-Hydroxytryptamine Involvement in Migraines
5-Hydroxytryptamine Involvement in Migraines Edith Hamel Pramod R. Saxena Migraine is a complex disorder that has been best described as the manifestation of a hereditary or predisposed sensitivity of neurovascular…
Spreading Depression
Spreading Depression Martin Lauritzen Richard P. Kraig The characteristic development of sensory disturbances during migraine auras suggests that the underlying mechanism is a disturbance of the neocortex, probably spreading depression…
Migraine Comorbidity
Migraine Comorbidity Kathleen Ries Merikangas Nancy C. D. Low Birthe Krogh Rasmussen Comorbidity, introduced by Feinstein, refers to the presence of any additional coexisting ailment in a patient with a…
Epidemiology of Migraine
Epidemiology of Migraine Birthe Krogh Rasmussen During the last decade studies of the epidemiology of migraine have clarified our understanding of the scope and distribution of the public health problem…
The Migraines: Introduction
The Migraines: Introduction Jes Olesen Peter J. Goadsby Migraine is an important and fascinating disorder. It is important because it is highly prevalent and severely disabling. The total sum of…
Human Models of the Headaches
Human Models of the Headaches Christina Kruuse Shazia Khan Afridi The unpredictable and episodic nature of many of the primary headaches introduces practical difficulties into research in this field, in…
Animal Models of Headache
Animal Models of Headache Andrew H. Ahn Peter J. Goadsby Animal models have been critical to our understanding of the neurobiology of primary headache syndromes, and entire volumes have been…
Triptan Signal Transduction
Triptan Signal Transduction Gareth W. John Peter J. Goadsby Seven serotonin (5-hydroxytryptamine; 5-HT)1B/1D receptor agonists derived from tryptamine, commonly termed triptans, are now in routine clinical use: almotriptan, eletriptan, frovatriptan,…
Ion Channels Relevant to Pain
Ion Channels Relevant to Pain Kevin Shields Arn van den Maagdenberg ION CHANNELS AND PAIN A wide variety of voltage- and ligand-gated ion channels are needed for the generation and…
