Neurophysiology of Migraines
Neurophysiology of Migraines Jean Schoenen Sheena Aurora Migraine is a disorder in which central nervous system (CNS) dysfunction might play a pivotal role. Because there are no consistent structural disturbances,…
Brain Metabolism in Migraines
Brain Metabolism in Migraines Pasquale Montagna K. Michael A. Welch INTRODUCTION Studies of brain metabolism in migraine are limited, largely because of the inherent difficulties in applying complex methodologies to…
Hemodynamics and Neuroimaging of Migraines
Hemodynamics and Neuroimaging of Migraines Margarita Sanchez del Rio Jes Olesen Hans-Christoph Diener The study of vascular mechanisms of migraine falls into three epochs: Throughout the nineteenth century and the…
Platelets and Immunology of Migraines
Platelets and Immunology of Migraines Rajiv Joseph Jacqueline deBelleroche Giovanni D’Andrea Andre Pradalier Platelets are anuclear cellular components of blood that function primarily to secure hemostasis. They are metabolically adapted…
Influence of Female Hormones on Migraines
Influence of Female Hormones on Migraines Hélène Massiou E. Anne MacGregor IHS AND WHO CODE NUMBERS 8.3.1 [G44.418] Exogenous hormone-induced headache 8.4.3 [G44.83] Estrogen-withdrawal headache A1.1.1 Pure menstrual migraine without…
Blood and Spinal Fluid in Migraines
Blood and Spinal Fluid in Migraines Paola Sarchielli Flemming W. Bach No biological markers of migraine have been identified as yet and migraine diagnosis remains primarily clinical. Many neurotransmitter pathways…
Neurogenic Inflammatory Mechanisms
Neurogenic Inflammatory Mechanisms Kirk W. Johnson Hayrunissa Bolay Migraine headache is an episodic disorder with heterogenous clinical features that could be promoted by complex intrinsic or extrinsic factors in susceptible…
Channelopathies and Their Possible Relation to Migraines
Channelopathies and Their Possible Relation to Migraines Dennis E. Bulman Daniela Pietrobon Ion channels are part of a large family of macromolecules whose functions include the control and maintenance of…
CGRP Involvement in Migraines
CGRP Involvement in Migraines Lars Edvinsson Richard Hargreaves The functional studies crucial to any hypothesis regarding primary (migraine and cluster) headaches rests on the classic observations of Ray and Wolff…
Nitric Oxide Involvement in Migraines
Nitric Oxide Involvement in Migraines Helle U. Iversen Uwe Reuter Over the years, many provoking factors have been studied in the search for migraine mechanisms (76). Glyceryl trinitrate (GTN) and…
