Alpha 1-Antitrypsin Deficiency
Risk • One of the most common inherited disorders (1 in 2500 in case of European ancestry; uncommon in Asians) • Less than 10% of individuals with AAT deficiency are…
Risk • One of the most common inherited disorders (1 in 2500 in case of European ancestry; uncommon in Asians) • Less than 10% of individuals with AAT deficiency are…
Risk • Risk factors include: advanced maternal age (>35 y); cesarean delivery; placenta previa; meconium; intrauterine fetal demise; placental abruption; meconium staining of the amniotic fluid; chorioamnionitis; and macrosomia. •…
Risk • Incidence in USA: 10% of Americans, incl physicians, will abuse alcohol at some point in their lives. • 1:5 surgical pts has some form of alcohol use disorder….
Risk • Incidence in USA: 1:100,000 • Race with highest prevalence: Unknown Perioperative Risks • Increased risk of periop renal failure, cardiomyopathy (arrhythmias and ventricular dysfunction), bleeding from coagulopathy •…
Risk • Also known as syndromic bile duct paucity • Affects cardiac, musculoskeletal, ocular, facial, and neurodevelopmental systems • Most common inherited disorder that causes chronic liver disease in children…
Risk • Risk of adrenal insufficiency: 1/1000 to 1/10,000 (if steroids used in prior y). • With steroids >20 mg/d (cortisol equivalent), >7 to 14 d within 1 y (large…
Risk • Prevalence 1:100,000 persons • M:F ratio: 1:1.8 Perioperative Risks • CV instability, labile BP, hypotension, shock • Hypovolemia, hyperkalemia, cardiac dysrhythmia • Limited response to vasopressors Perioperative Risks…
Risk • Recent data estimates the incidence at 190,000 cases per year in USA. True incidence is unknown due to difficulty in defining the disease and making the diagnosis. •…
Risk • Prevalence: <200,000 cases of porphyria in USA, AIP: 5 to 10 in 100,000 worldwide. • Highest in Northern Europeans. • More commonly manifests in females, typically third to…
Risk • People within USA: • Prevalence is 40 cases/million; incidence is 3 to 8 new cases/million/y. • Occurs with equal frequency in men and women and most frequently diagnosed…