Chapter 13 – Sympathomimetics
Abstract The autonomic nervous system (ANS) is a complex system of neurones that controls the body’s internal milieu. It is not under voluntary control and is anatomically distinct from the…
ANESTHESIA
Chapter 16 – Vasodilators
Abstract Sodium nitroprusside is usually administered as a 0.005–0.02% (50–200 μg/ml) intravenous infusion, the dose of 0.5–6 μg.kg−1.min−1 being titrated to effect. Chapter 16 Vasodilators Sodium Nitroprusside Sodium nitroprusside (SNP)…
Chapter 15 – Anti-Arrhythmics
Abstract The heart is composed of pacemaker, conducting and contractile tissue. Each has a different action potential morphology allowing the heart to function as a coordinated unit. The sino-atrial (SA)…
Chapter 9 – General Anaesthetic Agents
Abstract Our understanding of the mechanisms involved in the action of general anaesthetics has increased considerably in recent times and is discussed below. This is followed by sections discussing intravenous…
Chapter 14 – Adrenoceptor Antagonists
Abstract α-Adrenoceptor antagonists (α-blockers) prevent the actions of sympathomimetic agents on α-adrenoceptors. Certain α-blockers (phentolamine, phenoxybenzamine) are non-specific and inhibit both α1– and α2-receptors, whereas others selectively inhibit α1-receptors (prazosin)…
Chapter 11 – Local Anaesthetics
Abstract Individual nerve fibres are made up of a central core (axoplasm) and a phospholipid membrane containing integral proteins, some of which function as ion channels. Chapter 11 Local Anaesthetics…
Chapter 10 – Analgesics
Abstract Pain is defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage. Since pain is so highly subjective, it may also be described as…
Chapter 6 – Pharmacokinetic Modelling
Abstract Pharmacokinetics is the study of the way in which the body handles administered drugs. The use of mathematical models allows us to predict how plasma concentration changes with time…
Chapter 8 – Medicinal Chemistry
Abstract Structure–activity relationships (SAR) describe how the structure of related drugs influences their behaviour, for example whether they are agonists or antagonists. In order to understand how differences in drug…
Chapter 7 – Applied Pharmacokinetic Models
Abstract In the previous chapter we explored the mathematical principles and models that can be used to predict plasma concentrations of drugs, particularly compartment models. This chapter will discuss the…
