Dolasetron (Anzemet): See 5HT3 Antagonists. Droperidol (Inapsine) Indication: (1) Prevention/treatment of postoperative nausea and vomiting. Also used for (2) sedation, GA adjunct, treatment of delirium although alternate drugs are preferred…
(lower should remain OFF until after reperfusion & stabilization) • Foley catheter: Goal urine output >0.5 mL/kg/hr • PRBC in the OR; may also need FFP • Management before clamping…
• In pediatric patients a 20–24 gauge needle may be used for the first cannulation and then exchanged with a larger gauge over a guidewire • Proceed as described in…
• Consider bronchoscopy • Consider bag ventilation • Treat underlying problem BRONCHOSPASM Causes • Preexisting reactive airway disease (asthma) • Manipulation of upper airway (oral endoscopy) • ETT with inadequate…
PHARMACODYNAMICS • Ionization best correlates with onset of action. LAs exist in free equilibrium in both charged (ionized) and neutral (non-ionized) forms: • The ionized form binds to the receptor…
MAJOR FACTORS AFFECTING UPTAKE Solubility • Partition coefficients express relative solubility of anesthetic gas at equilibrium • Lower partition coefficients imply ↓ solubility, faster equilibration of partial pressure (alveolus ↔…
ADRENERGIC AGONISTS General comments: Act on α, β, or dopaminergic receptors (see the table below). May cause tachycardia, hypertension, arrhythmias, myocardial ischemia, and tissue necrosis with extravasation (administer centrally, treat…
• Clinical Considerations • Indications: Bolus dosing used for rapid sequence induction when aspiration is a risk (i.e., full stomach, trauma, diabetes mellitus, hiatal hernia, obesity, pregnancy); infusion useful in…
GENERAL PRINCIPLES • Lipophilic drugs produce rapid induction of general anesthesia • Most IV anesthetics exert effect through activation or augmentation of postsynaptic GABAA receptors (↑ chloride influx → hyperpolarization…
CHAPTER 8 Upper limb blocks Interscalene block Use this block for anaesthesia/analgesia of the shoulder joint (dislocation reduction), arm, elbow, and proximal forearm injuries or amputations (Fig. 8.1). Fig. 8.1…
