Introduction Since 1991, the global burden of disease has shifted from communicable to noncommunicable disease (NCDs), primarily due to prevention, mitigation, and treatment of infectious disease in low- and middle-income…
Introduction Cancer epidemiology provides the tools and methods to understand the cancer problem in any given population, from the local level up to the global level. Incidence, prevalence, and mortality…
MAC and Theories of Narcosis MAC Soon Connected to Theories of Narcosis How do inhaled anesthetics work? We understand the answer at a pharmacokinetic level. Anesthetics diffuse from the lungs…
Anesthetics and the Mind Can Inhaled Anesthetics Permanently Change the Brain? Anesthetics turn off the brain. At concentrations just slightly higher than anesthetic concentrations, the brain becomes isoelectric. Ponder that…
Finding Love Again PROMISES Written for our wedding We come today with promises in our pockets, Large words like always and forever, Difficult to grasp, like tumbling rockets. For the…
New Inhaled Anesthetics The Development of Modern Inhaled Anesthetics My anesthetic career began in 1952, between my first and second years of medical school. This coincided with the introduction of…
Walking in the Mountains Meeting Tom Hornbein John Severinghaus introduced me into the world of research, a world that became my life’s work and passion. However, John was instrumental in…
The Evolution of Pharmacokinetics Continuing Studies of Uptake To understand the action of anesthetic drugs, I needed to understand the process by which the drugs enter the body and are…
The Evolution of MAC Toward a Better Definition of MAC As described in Chapter 6, Giles Merkel and I collaborated from 1961 through 19631 to define the anesthetic potency of…
