Anesthesia Key

Anatomy The liver is divided into four lobes consisting of 50,000 to 100,000 individual hepatic lobules (Fig. 32-1). Blood flows past hepatocytes via sinusoids from branches of the portal vein…

Pharmacokinetics H1-receptor antagonists are well absorbed after oral administration, often reaching peak plasma concentrations within 2 hours (see Table 35-1).19,20 Many are highly protein bound, with ranges from 78% to…

The Glomerulus Structure and Function of the Glomerulus Glomeruli are found in the renal cortex and consist of a tuft of capillaries surrounded by Bowman’s capsule, the dilated blind end…

Epinephrine Epinephrine is the prototype sympathomimetic. It is a circulating hormone synthesized, stored, and released from the adrenal medulla. Its natural functions upon release into the circulation include regulation of…

Heart The heart increases in size during aging as a result of concentric ventricular hypertrophy. This occurs in response to the increase in left ventricular afterload. This increase in afterload…

Antidepressants are logically classified based on their chemical structures and their acute neuropharmacologic effects (Table 43-2). The precise mechanism by which antidepressants work is unknown, but they appear to act…

Structure–Activity Relationships All corticosteroids are constructed on the same primary molecular framework, designated as the steroid nucleus (see Fig. 40-1). Changes in molecular structure may result in altered biologic responses…

The central focus of treating acid–base disturbances is the understanding of the biochemistry of the hydrogen ion. Hydrogen ion concentrations in the various body fluid compartments are precisely regulated in…

Drug Resistance Resistance to chemotherapeutic drugs often occurs and has many causes.3 Some chemotherapy agents lead to induction of drug-metabolizing enzymes in the liver, other tissues, or tumor cells, accelerating…