Pharmacology Principles
Figure 3.1 Zero vs. first order kinetics (Image Courtesy J. Ehrenfeld) First-order pharmacokinetics : Most drugs are metabolized via processes that obey first-order kinetics, meaning that the rate of drug metabolism…
Fluids and Transfusion Therapy
where EBV represents estimated blood volume, Hcti is initial hematocrit and Hctt is threshold hematocrit for transfusion. EBV is estimated to be 75 mL/kg for men and 65 mL/kg for…
Anesthetic Techniques: General, Sedation, MAC
M → Machine S → Suction M → Monitors A → Airway I → IV D → Drugs S → Special The first “M” stands for the anesthesia Machine. In performing a machine check, one should use a written check list in order to…
Pharmacology of Adjunct Agents
Receptor Receptor site action α-1 Glycogenolysis, gluconeogenesis, constricts vascular smooth muscle, relaxes GI tract α-2 Constricts vascular smooth muscle, decreases insulin secretion and norepinephrine release β-1 Increases heart rate and…
History of Anesthesia and Introduction to the Specialty
Figure 2.1 “Ether day, 1846” pictured are Gilbert Abbott (the patient), John Collins Warren, M.D. (the surgeon), William T. G. Morton (the anesthetist) and Henry J. Bigelow, M.D. (the junior…
Pharmacology of Local Anesthetics
Fiber type Local anesthetic sensitivity Size Myelination A + Large Yes B ++ Medium Yes C +++ Small No pH: Most local anesthetics are weak bases that exist as an equilibrium…
Pharmacology of Intravenous Anesthetic Agents
, John W. Wolfe2 and Jesse M. Ehrenfeld3 (1) Department of Anesthesia, Indiana University School of Medicine, Wishard Memorial Hospital, Indianapolis, IN, USA (2) Department of Anesthesiology, Indiana University Hospital, Indiana University School of…
How to Be a “Star” Student, Career Options, and the Match
Figure 1.1 Key milestones on the road to the match (Figure Courtesy J. Ehrenfeld) As with most specialties, applicants must use the ERAS system , whether applying for PGY1 or…
Pharmacology of Inhalational Anesthetics
Agent Vapor pressure (20 °C) Blood: gas partition coefficienta Fat: blood partition coefficient Metabolism Pungencyb N2O 38,770 mmHg 0.46 2.3 0 None Desflurane 669 mmHg 0.42 27 0.02 % High…
The Essentials of Patient Education in the Emergency Department
The Essentials of Patient Education in the Emergency Department Robin J. Trupp Elsie M. Selby Introduction Heart failure is a complex chronic condition associated with great morbidity, mortality, and economic…
