Local and Regional Anesthesia in the Elderly


Bolus

Infusion

Midazolam 0.5–2 mg (titrated up to 0.07 mg/kg)

Remifentanil 0.05–0.0625 μg/kg/min

Fentanyl 0.25–0.5 μg/kg

Propofol 1.5–3 mg/kg/h (25–50 μg/kg/min)

Ketamine 0.1–0.2 mg/kg

Dexmedetomidine 0.2–0.7 μg/kg/h




Table 17.2
Suggested anesthetic doses for nerve block
















































































Nerve block and drug

Bolus dose

Infusion

Useful adjunct

Spinal

Isobaric bupivacaine

5–15 mg

N/A

Epinephrine 0.3 mg
     
Morphine 0.1 mg
     
Fentanyl 10–25 μg

Epidural

Bupivacaine

0.5 %, 5–10 mL

0.125 %, 5–10 mL/h

Morphine 0.05–0.1 mg/mL
     
Fentanyl 1–2 μg/mL

Levobupivacaine

0.5 %, 5–10 mL

0.125 %, 5–10 mL/h

Morphine 0.05–1 mg/mL
     
Fentanyl 1–2 μg/mL

Ropivacaine

0.5 %, 5–10 mL

0.2 %, 5–10 mL/h

Morphine 0.05–1 mg/mL
     
Fentanyl 1-2 μg/mL

Peripheral

Bupivacaine

0.5 %, 20 mL

0.2 %, 5–10 mL

N/A

Levobupivacaine

0.5 %, 20 mL

0.2 %, 5–10 mL

N/A

Ropivacaine

0.5 %, 20 mL

0.2 %, 5–10 mL

N/A




References



1.

Roy RC. Choosing general versus regional anesthesia for the elderly. Anesthesiol Clin North America. 2000;18:91–104, vii.


2.

Gustafson Y, Berggren D, Brannstrom B, Bucht G, Norberg A, Hansson LI, Winblad B. Acute confusional states in elderly patients treated for femoral neck fracture. J Am Geriatr Soc. 1988;36:525–30.PubMed


3.

O’Keeffe ST, Ni CA. Postoperative delirium in the elderly. Br J Anaesth. 1994;73:673–87.PubMed


4.

Hole A, Terjesen T, Breivik H. Epidural versus general anaesthesia for total hip arthroplasty in elderly patients. Acta Anaesthesiol Scand. 1980;24:279–87.PubMed


5.

Papaioannou A, Fraidakis O, Michaloudis D, Balalis C, Askitopoulou H. The impact of the type of anaesthesia on cognitive status and delirium during the first postoperative days in elderly patients. Eur J Anaesthesiol. 2005;22:492–9.PubMed


6.

Haan J, van Kleef JW, Bloem BR, Zwartendijk J, Lanser JB, Brand R, van der Does I, Krul EJ, Elshove HM, Moll AC. Cognitive function after spinal or general anesthesia for transurethral prostatectomy in elderly men. J Am Geriatr Soc. 1991;39:596–600.PubMed


7.

Fong HK, Sands LP, Leung JM. The role of postoperative analgesia in delirium and cognitive decline in elderly patients: a systematic review. Anesth Analg. 2006;102:1255–66.PubMed


8.

Sprung J, Gajic O, Warner DO. Review article: age related alterations in respiratory function—anesthetic considerations. Can J Anaesth. 2006;53:1244–57.PubMed


9.

Halaszynski TM. Pain management in the elderly and cognitively impaired patient: the role of regional anesthesia and analgesia. Curr Opin Anaesthesiol. 2009;22:594–9.PubMed


10.

Rasmussen LS, Johnson T, Kuipers HM, Kristensen D, Siersma VD, Vila P, Jolles J, Papaioannou A, Abildstrom H, Silverstein JH, Bonal JA, Raeder J, Nielsen IK, Korttila K, Munoz L, Dodds C, Hanning CD, Moller JT. Does anaesthesia cause postoperative cognitive dysfunction? A randomised study of regional versus general anaesthesia in 438 elderly patients. Acta Anaesthesiol Scand. 2003;47:260–6.PubMed


11.

Gulur P, Nishimori M, Ballantyne JC. Regional anaesthesia versus general anaesthesia, morbidity and mortality. Best Pract Res Clin Anaesthesiol. 2006;20:249–63.PubMed


12.

Chung F, Meier R, Lautenschlager E, Carmichael FJ, Chung A. General or spinal anesthesia: which is better in the elderly? Anesthesiology. 1987;67:422–7.PubMed


13.

Cohendy R, Brougere A, Cuvillon P. Anaesthesia in the older patient. Curr Opin Clin Nutr Metab Care. 2005;8:17–21.PubMed


14.

Modig J, Borg T, Karlstrom G, Maripuu E, Sahlstedt B. Thromboembolism after total hip replacement: role of epidural and general anesthesia. Anesth Analg. 1983;62:174–80.PubMed


15.

Modig J, Maripuu E, Sahlstedt B. Thromboembolism after total hip replacement: a prospective investigation of 94 patients with emphasis of the efficacy of lumbar epidural anesthesia in prophylaxis. Reg Anesth. 1986;11:72–9.


16.

Keith I. Anaesthesia and blood loss in total hip replacement. Anaesthesia. 1977;32:444–50.PubMed


17.

Sorenson RM, Pace NL. Anesthetic techniques during surgical repair of femoral neck fractures. A meta-analysis. Anesthesiology. 1992;77:1095–104.PubMed


18.

Matot I, Oppenheim-Eden A, Ratrot R, Baranova J, Davidson E, Eylon S, Peyser A, Liebergall M. Preoperative cardiac events in elderly patients with hip fracture randomized to epidural or conventional analgesia. Anesthesiology. 2003;98:156–63.PubMed


19.

Yeager MP, Glass DD, Neff RK, Brinck-Johnsen T. Epidural anesthesia and analgesia in high-risk surgical patients. Anesthesiology. 1987;66:729–36.PubMed


20.

Garcia Collada JC, Pereda Marin RM, Miralles Serrano EM, Garrote Martinez AI, Pacheco Lopez JF. Axillary brachial plexus block in an elderly patient with a previous 48-h standing acute myocardial infarct. Acta Anaesthesiol Scand. 2004;48:387–8.PubMed


21.

Bode Jr RH, Lewis KP, Zarich SW, Pierce ET, Roberts M, Kowalchuk GJ, Satwicz PR, Gibbons GW, Hunter JA, Espanola CC. Cardiac outcome after peripheral vascular surgery. Comparison of general and regional anesthesia. Anesthesiology. 1996;84:3–13.PubMed


22.

Breen P, Park KW. General anesthesia versus regional anesthesia. Int Anesthesiol Clin. 2002;40:61–71.PubMed


23.

Nielsen KC, Steele SM. Outcome after regional anaesthesia in the ambulatory setting—is it really worth it? Best Pract Res Clin Anaesthesiol. 2002;16:145–57.PubMed


24.

Brull SJ. Choice of regional versus general anesthesia. In: McLeskey CH, editor. Geriatric anesthesiology. Baltimore: Williams & Wilkins; 1997. p. 361–6.


25.

Kanto J, Maenpaa M, Mantyla R, Sellman R, Valovirta E. Effect of age on the pharmacokinetics of diazepam given in conjunction with spinal anesthesia. Anesthesiology. 1979;51:154–9.PubMed


26.

Arisaka H, Sakuraba S, Takeda J. Effects of spinal anesthesia on the electroencephalogram in the elderly. Acta Anaesthesiol Belg. 2008;59:15–7.PubMed


27.

Kurup V, Ramani R, Atanassoff PG. Sedation after spinal anesthesia in elderly patients: a preliminary observational study with the PSA-4000. Can J Anaesth. 2004;51:562–5.PubMed


28.

Sieber FE, Gottshalk A, Zakriya KJ, Mears SC, Lee H. General anesthesia occurs frequently in elderly patients during propofol-based sedation and spinal anesthesia. J Clin Anesth. 2010;22:179–83.PubMed


29.

Jacobs JR, Reves JG, Marty J, White WD, Bai SA, Smith LR. Aging increases pharmacodynamic sensitivity to the hypnotic effects of midazolam. Anesth Analg. 1995;80:143–8.PubMed


30.

Maitre PO, Buhrer M, Thomson D, Stanski DR. A three-step approach combining Bayesian regression and NONMEM population analysis: application to midazolam. J Pharmacokinet Biopharm. 1991;19:377–84.PubMed


31.

Bell GD, Spickett GP, Reeve PA, Morden A, Logan RF. Intravenous midazolam for upper gastrointestinal endoscopy: a study of 800 consecutive cases relating dose to age and sex of patient. Br J Clin Pharmacol. 1987;23:241–3.PubMedPubMedCentral


32.

CPS: compendium of pharmaceuticals and specialties. 38th ed. Ottawa: Canadian Pharmacists Association; 2003. p. 1003–8.


33.

White PF, Boure B. Outpatient anesthesia for geriatric patients. In: McLeskey CH, editor. Geriatric anesthesiology. Baltimore: Williams & Wilkins; 1997. p. 441–57.


34.

Munoz HR, Dagnino JA, Rufs JA, Bugedo GJ. Benzodiazepine premedication causes hypoxemia during spinal anesthesia in geriatric patients. Reg Anesth. 1992;17:139–42.PubMed


35.

Fernandez-Galinski D, Rue M, Moral V, Castells C, Puig MM. Spinal anesthesia with bupivacaine and fentanyl in geriatric patients. Anesth Analg. 1996;83:537–41.PubMed


36.

Pavlin DJ, Coda B, Shen DD, Tschanz J, Nguyen Q, Schaffer R, Donaldson G, Jacobson RC, Chapman CR. Effects of combining propofol and alfentanil on ventilation, analgesia, sedation, and emesis in human volunteers. Anesthesiology. 1996;84:23–37.PubMed


37.

Vinik HR, Bradley Jr EL, Kissin I. Triple anesthetic combination: propofol-midazolam-alfentanil. Anesth Analg. 1994;78:354–8.PubMed


38.

McHardy FE, Fortier J, Chung F, Krishnathas A, Marshall SI. A comparison of midazolam, alfentanil and propofol for sedation in outpatient intraocular surgery. Can J Anaesth. 2000;47:211–4.PubMed


39.

Rewari V, Madan R, Kaul HL, Kumar L. Remifentanil and propofol sedation for retrobulbar nerve block. Anaesth Intensive Care. 2002;30:433–7.PubMed


40.

Aydin ON, Ugur B, Kir E, Ozkan SB. Effect of single-dose fentanyl on the cardiorespiratory system in elderly patients undergoing cataract surgery. J Clin Anesth. 2004;16:98–103.PubMed


41.

Minto CF, Schnider TW, Egan TD, Youngs E, Lemmens HJ, Gambus PL, Billard V, Hoke JF, Moore KH, Hermann DJ, Muir KT, Mandema JW, Shafer SL. Influence of age and gender on the pharmacokinetics and pharmacodynamics of remifentanil. I. Model development. Anesthesiology. 1997;86:10–23.PubMed


42.

Krenn H, Deusch E, Jellinek H, Oczenski W, Fitzgerald RD. Remifentanil or propofol for sedation during carotid endarterectomy under cervical plexus block. Br J Anaesth. 2002;89:637–40.PubMed


43.

Mingus ML, Monk TG, Gold MI, Jenkins W, Roland C. Remifentanil versus propofol as adjuncts to regional anesthesia. Remifentanil 3010 Study Group. J Clin Anesth. 1998;10:46–53.PubMed


44.

Marrocco-Trischitta MM, Bandiera G, Camilli S, Stillo F, Cirielli C, Guerrini P. Remifentanil conscious sedation during regional anaesthesia for carotid endarterectomy: rationale and safety. Eur J Vasc Endovasc Surg. 2001;22:405–9.PubMed


45.

Paris A, Tonner PH. Dexmedetomidine in anaesthesia. Curr Opin Anaesthesiol. 2005;18:412–8.PubMed


46.

Kunisawa T, Hanada S, Kurosawa A, Suzuki A, Takahata O, Iwasaki H. Dexmedetomidine was safely used for sedation during spinal anesthesia in a very elderly patient. J Anesth. 2010;24:938–41.PubMed


47.

Hong JY, Kim WO, Yoon Y, Choi Y, Kim SH, Kil HK. Effects of intravenous dexmedetomidine on low-dose bupivacaine spinal anaesthesia in elderly patients. Acta Anaesthesiol Scand. 2012;56:382–7.PubMed


48.

Austin TR. Ketamine hydrochloride: a potent analgesic. Br Med J. 1976;2:943.PubMedPubMedCentral


49.

Sadove MS, Shulman M, Hatano S, Fevold N. Analgesic effects of ketamine administered in subdissociative doses. Anesth Analg. 1971;50:452–7.PubMed


50.

Idvall J, Ahlgren I, Aronsen KR, Stenberg P. Ketamine infusions: pharmacokinetics and clinical effects. Br J Anaesth. 1979;51:1167–73.PubMed


51.

Frey K, Sukhani R, Pawlowski J, Pappas AL, Mikat-Stevens M, Slogoff S. Propofol versus propofol-ketamine sedation for retrobulbar nerve block: comparison of sedation quality, intraocular pressure changes, and recovery profiles. Anesth Analg. 1999;89:317–21.PubMed


52.

Rosenberg MK, Raymond C, Bridge PD. Comparison of midazolam/ketamine with methohexital for sedation during peribulbar block. Anesth Analg. 1995;81:173–4.PubMed


53.

Kirkpatrick T, Cockshott ID, Douglas EJ, Nimmo WS. Pharmacokinetics of propofol (diprivan) in elderly patients. Br J Anaesth. 1988;60:146–50.PubMed


54.

Schnider TW, Minto CF, Gambus PL, Andresen C, Goodale DB, Shafer SL, Youngs EJ. The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers. Anesthesiology. 1998;88:1170–82.PubMed


55.

Vuyk J, Oostwouder CJ, Vletter AA, Burm AG, Bovill JG. Gender differences in the pharmacokinetics of propofol in elderly patients during and after continuous infusion. Br J Anaesth. 2001;86:183–8.PubMed

Oct 25, 2017 | Posted by in Uncategorized | Comments Off on Local and Regional Anesthesia in the Elderly

Full access? Get Clinical Tree

Get Clinical Tree app for offline access