Airway Management

Chapter 119 Airway Management




Accurate assessment and safe management of the airway of a critically ill child is the essential first step in providing effective intensive care. It requires understanding of the anatomic and physiologic changes that occur from birth through adolescence, recognition of congenital and acquired airway abnormalities, appreciation of the pathophysiologic consequences of airway manipulation, and preparation for airways that may potentially be difficult to manage.



Anatomic Considerations


The configuration of the child’s airway changes dramatically from birth to adulthood (Figure 119-1). The nose is the site of nearly half of the total respiratory resistance to air flow at all ages. The infant’s nose is short, soft, and flat, with small, nearly circular nares. The nasal valve, the narrowest portion of the nasal airway, approximately 1 cm proximal to the alar rim in newborns, measures only about 20 mm2.1,2 By 6 months, dimensions of the nares have nearly doubled, but they are still easily occluded by edema, secretions, or external pressure. Although an infant is perhaps not as much the obligate nose breather as commonly assumed, signs of airway obstruction frequently develop when the infant’s nose is blocked.3,4



In infancy the mandible is small and the basicranium (which provides the roof of the nasopharynx) is flat, creating a small oral cavity. Over the years of its development, the jaw grows primarily down and forward, with the ramus increasing in height and width. The posterior portion of the basicranium develops a progressively more rounded configuration through childhood, which results in a larger nasal airway to meet the need for increased air flow (and provides a chamber for the resonance of adult speech).


Under normal conditions, the genioglossus muscle and other muscles of the pharynx and larynx help maintain airway patency. Both tonic and phasic inspiratory activity synchronized with phrenic contraction have been noted in animal and human studies. In particular, the genioglossus increases the dimensions of the pharyngeal airway by displacing the tongue anteriorly.5 In the infant and young child, the tongue is large relative to the bony structures surrounding it and the cavities they form. Relatively little displacement is possible at any time, and loss of tone during sleep, sedation, or central or peripheral nervous system dysfunction is more likely than in older patients to allow the tongue to relax into the posterior pharynx and cause upper airway obstruction.


The infant larynx is high in the neck at birth, with the epiglottis at the level of the first cervical vertebra and overlapping the soft palate. This approximation of structures, in combination with the relatively large tongue and small mandible, probably contributes to the vulnerability to airway obstruction in infants and young children. By 6 months the epiglottis has moved to about the level of the third cervical vertebra and is separate from the palate. It continues to descend to its adult position at about the fifth or sixth cervical vertebra by early adolescence. The infant epiglottis is soft and omega shaped, in contrast with the more rigid, flatter adult structure, and it has greater potential to occlude the airway. The immature larynx is funnel shaped, with the subglottic portion angled posteriorly relative to the supraglottic portion rather than forming a straight vertical column, as seen in adults. The larynx tapers to the cricoid cartilage, the narrowest point in the child’s extrathoracic airway.


The internal dimensions of the trachea in a newborn are approximately one third those of an adult, and absolute resistance to air flow is higher in newborns than in older children and adults. Because the most important factor determining resistance (R) is the radius (r) of an airway (R proportional to 8 l/r4), small changes in airway diameter in infants or young children as a consequence of edema or secretions have a far greater effect on resistance than similar changes in larger patients (see Figure 119-1).



Basic Airway Management


Airway management depends on a brisk assessment of the patient’s breathing and knowledge of the likely progression of the airway problem, that is, deterioration versus improving function. In virtually any setting in which respiratory difficulty is suspected, oxygen should be administered until the specific abnormality can be identified and adequately treated. Although extreme hypercarbia usually is well tolerated, hypoxia is routinely catastrophic and is not necessarily obvious on initial examination. From the alveolar air equation, it is obvious that hypercarbia produces hypoxia at low fraction of inspired oxygen (FiO2) (Table 119-1). If the patient is breathing spontaneously, attention is directed first to signs of upper airway obstruction, including absence of audible or palpable air flow, stertorous sounds, stridor, or a rocking chest and abdominal motion rather than the normal, smooth rise and fall that should occur with inspiration and expiration.


Table 119–1 Impact of Providing Supplemental Oxygen During Hypercarbia on Alveolar Oxygen Tension















Alveolar gas equation: PaO2 = FiO2 (PB – Ph2o) – PaCO2/0.8
Room air, normocarbia: PaO2 = 0.21 (760 – 47) – 40/0.8 = 99 mm H2O
Room air, hypercarbia: PaO2 = 0.21 (760 – 47) – 80/0.8 = 50 mm H2O
Supplemental O2, hypercarbia: PAO2 = 0.4 (760 – 47) – 80/0.8 = 185 mm H2O

FiO2, Fraction of inspired oxygen; PAO2, partial pressure of oxygen, alveolar.


An alert child with normal neuromuscular function usually instinctively assumes a body position that minimizes upper airway obstruction. However, a child with an altered level of consciousness or severe neuromuscular weakness may be unable to maintain a patent airway because of the inability to alter his or her position or maintain adequate glossopharyngeal muscle tone.





Oxygen Delivery Devices





Masks


A variety of masks are available for delivering oxygen. Simple masks fit loosely. The oxygen concentration delivered varies, depending on the patient’s inspiratory flow rate and the oxygen flow into the system. Partial rebreathing masks incorporate some sort of reservoir, usually a bag below the chin. Provided that flow into the system exceeds the patient’s minute ventilation and that the bag does not collapse on inspiration, little carbon dioxide is inhaled, and concentrations of oxygen up to about 60% can be achieved. Nonrebreathing masks must fit snugly. They incorporate a mask, reservoir, and one-way valves that vent expired gas but do not permit inspiration of room air. As a result, they can deliver close to 100% oxygen.



Noninvasive Positive Pressure Ventilation


Continuous positive airway pressure (CPAP) delivers high concentrations of oxygen and maintains positive airway pressure in the spontaneously breathing patient. CPAP is applied with an oxygen source connected to either a tight-fitting nasal or full-face mask or helmet in children or via nasal prongs in the neonate and older infant. CPAP offers the benefit of maintaining alveolar expansion and decreases work of breathing for many patients, particularly those with pulmonary parenchymal disease, as well as for some patients with airway obstruction related to poor upper airway tone or laryngeal, tracheal, or bronchomalacia.


Like CPAP, bilevel positive airway pressure (BiPAP) can be provided by mask, but it requires a ventilator to assist with flow delivery. The patient’s inspiratory effort triggers the BiPAP machine to deliver decelerating flow in order to reach a preset pressure, defined as inspiratory positive airway pressure. When a patient’s own inspiratory flow falls below a preset amount, ventilatory assistance ceases and maintains expiratory airway pressure at a predetermined value (typically between 5 and 10 mm Hg). Uses in the pediatric intensive care unit (PICU) include upper airway obstruction, atelectasis, exacerbations of neuromuscular disorders, support for mild to moderate respiratory failure, and as an assist in weaning patients from invasive mechanical ventilation.


Both CPAP and BiPAP offer the advantage of providing respiratory support without endotracheal intubation but require that the child tolerate a close-fitting mask. A more extensive discussion of CPAP and BiPAP is available in Chapter 49, Mechanical Ventilation and Respiratory Care.



Establishing a Functional Airway


A patient who is apneic or in very severe respiratory distress requires ventilation assisted initially with a bag and mask. Probably no skill is more important for the intensivist than the ability to provide effective manual bag-mask ventilation. It can be lifesaving while preparation for endotracheal intubation proceeds or when intubation cannot be accomplished. Effective technique requires positioning the patient adequately to open the upper airway, achieving a good mask-face seal, inserting an oral or nasal airway if needed, and generating an adequate tidal volume, coordinating manual breaths with patient efforts when they are present. Poor technique results in ineffective oxygenation and ventilation, gastric insufflation, and increased risk of aspiration.


If the child is too weak or obtunded to maintain pharyngeal tone independently, the head should be placed on a thin cushion to cause slight cervical spine flexion and gentle extension at the atlantooccipital joint. In infants, the large occipitofrontal diameter makes the cushion unnecessary, although a thin pad under the shoulders may be useful. It appears that aligning the external auditory meatus with the sternal notch is a reasonable guide to appropriate positioning. Current recommendations are to avoid overextending the baby’s very flexible cervical spine, which may stretch and compress the trachea and potentiate, rather than relieve, obstruction. Studies have questioned the existence of this phenomenon but to date have included a very small number of infants, all with normal airways.9 Appropriate head tilt separates the tongue from the posterior pharyngeal wall. If airway obstruction persists, the chin can be pulled forward by encircling the mandible behind the lower incisors between the thumb and fingers. The most effective means of relieving functional obstruction is the so-called triple airway maneuver: With the fingers behind the vertical ramus of the jaw, the mandible is displaced downward, forward, and finally upward again until the mandible and lower incisors are anterior to the maxilla. This action effectively pulls the tongue forward and away from the pharyngeal wall.


In some patients, establishing a functional airway is sufficient to allow resumption of effective spontaneous ventilation. In other patients, steady positive airway pressure is necessary to overcome residual obstruction. If breathing remains inadequate, manual ventilation is necessary. Effective ventilation requires a good mask fit. The mask should sit smoothly on the bridge of the nose and the bony prominence of the chin. It is important to avoid airway occlusion with the mask or hand or pressure on eyes, soft nasal structures, or branches of the trigeminal and facial nerves. A good mask fit is predictably difficult in a patient without teeth, a very flat or prominent nose, or micrognathia. Insertion of a nasal or oropharyngeal airway may help maintain an adequate airway. Once a good mask fit is ensured, ventilation may be assisted.


Two types of bags are in general use: self-inflating resuscitation bags and standard anesthesia bags. Because self-inflating bags vary substantially, specific directions for their use must be followed carefully. All bags incorporate an adapter to connect to a mask or endotracheal tube, a bag, a pressure-relief valve, and a port for fresh gas inflow. Most bags designed for children have pressure-relief valves designed to pop off at 35 to 45 cm H2O pressure to prevent excessive volume delivery and subsequent barotrauma. In patients with very poor compliance or increased airway resistance, it may be necessary to bypass this valve temporarily to provide effective ventilation. Most systems incorporate valves that prevent rebreathing. Fresh gas flows through the valve on spontaneous inspiration (negative pressure) or on creation of positive pressure by squeezing the bag (Figure 119-3). Exhaled gas is vented to the atmosphere. Not all systems allow spontaneous breathing; those that do demand that the patient generate at least a little negative pressure, so a good mask fit is necessary. Holding the mask above the patient’s face provides no supplemental oxygen. The percentage of oxygen delivered depends on the percentage of oxygen from the source, the fresh gas flow rate, and the respiratory rate, which determines the time available for the bag to refill. Most systems require some sort of reservoir assembly in addition to the self-inflating bag to prevent entrainment of room air. With a reservoir, 100% oxygen may be delivered; without a reservoir, most deliver less than 50%.



Anesthesia bags require flow from a source of gas under pressure in order to expand. Many variations have been reviewed extensively in the anesthesia literature. These circuits depend on the location of the fresh gas inflow and overflow valves, the rate of fresh gas flow, the respiratory rate, tidal volume, carbon dioxide production, and whether ventilation is spontaneous or controlled. Many ICUs use the Mapleson D configuration, with the fresh gas source attached just distal to the patient connection. The overflow valve is proximal to the reservoir bag. During expiration, the patient’s exhaled tidal volume mixes with fresh gas flowing into the system and accumulates in the tubing and bag. With sufficiently high fresh gas flow, alveolar gas is washed to the overflow valve and eliminated from the circuit. The system requires higher fresh gas flow to avoid rebreathing during spontaneous ventilation than during controlled breathing, but a safe rule of thumb recommends fresh gas flow two to three times the minute ventilation. During controlled ventilation, a minimum of 100 mL/kg/min ensures that carbon dioxide elimination is proportional to minute ventilation.10,11 At flows less than 90 mL/kg/min, increasing ventilation may only increase CO2 rebreathing.



Endotracheal Intubation


The pediatric intensivist is frequently called upon to intubate critically ill patients when brief periods of ventilation with a bag and mask are inadequate to reverse the underlying disorder. Few of these intubations are performed under the optimal conditions commonly attainable in the operating room, that is, relatively healthy children with empty stomachs who have previously been sedated and are intubated in a controlled environment with all members of the team experienced in and prepared for airway management. Instead, patients are often critically unstable and require intubation suddenly, often in settings where the procedure is not routine. Intubation often is viewed only as a means to an end, namely, mechanical ventilation. However, it is associated with profound physiologic effects that may dramatically affect the patient. The intensivist’s appreciation of these factors and ability to minimize the adverse physiologic consequence of airway manipulation may as decisively determine patient outcome as his or her skill in providing the intensive care that follows.



Indications





Neuromuscular Dysfunction


For additional information on neuromuscular dysfunction, see Chapter 58.


Neuromuscular dysfunction or severe chest wall instability (or deformity) may cause failure of the bellows apparatus for breathing.17 Initially, tidal volume remains normal or at least sufficient to maintain normal blood gas tensions, but vital capacity and maximal inspiratory and expiratory pressures decrease. Inability to take a deep breath or cough forcefully risks progressive segmental or lobar atelectasis, inability to clear secretions, bronchial obstruction, and possible major airway obstruction with sudden severe hypoxia or carbon dioxide retention. Increasing weakness results in progressively smaller tidal volumes, loss of upper airway tone, and, ultimately, inadequate minute ventilation. Bulbar dysfunction may lead to aspiration as a result of impaired swallowing and inadequate cough.


Measurement of ventilatory reserve provides a better assessment of the patient’s need for ventilatory assistance than does arterial blood gas tensions alone. Maximum negative inspiratory pressure and vital capacity are two simple, commonly used tests for this purpose. A variety of other measures also help assess respiratory “strength,” but most are difficult to perform in sick, uncooperative infants and children. Patients with diffuse neuromuscular weakness of any cause, spinal cord dysfunction above the level of T6, or loss of phrenic nerve or diaphragm function are particularly prone to respiratory failure.18 Because of the extreme compliance of their chest walls and relative ineffectiveness of intercostal muscles, infants younger than approximately 6 months tolerate diaphragmatic paralysis poorly.1923


Many patients with neuromuscular weakness respond well to noninvasive forms of ventilatory support.17,24 Decisions about the best approach to airway management should be based on the nature and likely progression of the illness, the child’s maturity and level of consciousness, and the timing of the onset of respiratory insufficiency. In an emergency, endotracheal intubation is likely to be safest, with transition to noninvasive support when careful planning allows.24



Failure of Central Nervous System Regulation of Ventilatory Drive


Failure of central nervous system regulation of ventilatory drive may prompt intubation (see Chapters 54 and 57). Centrally mediated hypoventilation is manifest as CO2 retention, usually in the absence of increased work of breathing. On occasion the decision to support ventilation may be based on observing abnormal ventilatory patterns in anticipation of neurologic deterioration. Loss of protective airway reflexes, including the cough and gag reflexes, can result from central nervous system depression, cranial nerve abnormalities, or severe motor weakness. In such patients, intubation is indicated to prevent aspiration. Intubation may be appropriate in anticipation of the need to protect the airway and support ventilation during deep sedation for procedures or diagnostic studies.




Physiologic Effects of Intubation


Laryngoscopy is a potent physiologic stimulus (Box 119-2).25,26 At the very least, laryngoscopy is uncomfortable, causing significant pain and severe anxiety, especially in children who cannot understand or accept the need for it. Laryngoscopy causes an increase in systemic blood pressure and heart rate initiated by pressure on the back of the tongue or lifting the epiglottis.27 This effect is augmented by endotracheal intubation and suction.28 Nodal or ventricular dysrhythmias may occur. Sensory impulses triggering this reflex probably are carried along the vagus nerve supplying the base of the tongue, epiglottis, and trachea. The efferent limb is less well defined but most likely is the product of enhanced sympathetic activity. Infants respond more variably than do older patients. Hypertension develops in most patients, but a few become hypotensive, especially if they are hypoxic.29 They may demonstrate moderate-to-severe bradycardia rather than tachycardia, perhaps as a consequence of their greater parasympathetic tone. Sedation and light anesthesia decrease but do not obliterate the hypertension and tachycardia; surface anesthesia and deeper general anesthesia are more effective.30 Children with previous hypertension display an exaggerated vasopressor response. Sedation and neuromuscular blockade during airway manipulation in infants minimizes the associated bradycardia and systemic hypertension.3135 The impact of positive pressure ventilation on cardiac performance depends on the underlying disorder (discussed in Chapter 26) but should be carefully considered in preparation for intubation.



Laryngoscopy and intubation are potent stimulators of laryngospasm and may cause bronchoconstriction, especially in patients with a history of reactive airway disease. Increased airway resistance probably results from parasympathetic stimulation, with release of acetylcholine and stimulation of muscarinic receptors on airway smooth muscle, especially large central airways.


During intubation, oxygen delivery to the patient is commonly interrupted. Ineffective breathing or apnea increases the likelihood of hypoxia, especially in children, with their relatively low functional residual volume and higher basal metabolic rate. Patients with severe pulmonary disease and abnormally low functional reserve capacity are at particular risk.31,34 During apnea, carbon dioxide tension increases at a rate of 3 to 4 mm Hg/min in healthy, sedated adults and probably more rapidly in children, particularly those with severe cardiopulmonary disease or increased metabolic rate resulting from fever, sepsis, or pain.36,37


ICP rises immediately during laryngoscopy even in patients without intracranial pathology before changes in blood gas tensions occur.30,32,38,39 Cerebral metabolic rate and blood flow increase. Hypoxia, hypercarbia, and diminished jugular venous drainage, particularly in struggling patients, contribute further to increases in cerebral blood volume and increased intracranial pressure. Although normally very transient, such intracranial hypertension may predispose patients with coagulopathies or vascular malformations to intracranial hemorrhage. Systemic hypertension in patients with impaired autoregulation of the cerebral circulation (e.g., sick infants or patients with a variety of intracranial disorders) and impedance to jugular venous return by jugular compression, pneumothorax, or coughing and struggling stress both the arterial and venous sides of the cerebral circulation. In patients with poor intracranial compliance, this effect is exaggerated and prolonged. In infants without primary central nervous system disease, muscle paralysis (even without sedation or analgesia) effectively blocks the rise in ICP associated with intubation.34 The systemic hypertensive response is generally unaffected by neuromuscular blocking agents but can be modified by analgesia and sedation or intravenous anesthesia.


Patients with severe pulmonary hypertension are at high risk for adverse effects of laryngoscopy. Decreased oxygenation and progressive hypercarbia lead to elevated pulmonary artery pressure. The noxious stimulus of visualizing the airway in itself may precipitate life-threatening hypertension.



Recognition of a Difficult Airway


Recognition of a difficult airway is important if potentially lethal surprises in airway management are to be minimized (Box 119-3). Although the intensivist is usually focused on the immediate physiologic disturbances affecting the patient, careful preparation and as thorough an evaluation of each individual patient as is possible is critical. Key components of the history and physical examination, as well as the clinical scenario, can provide insight into potential problem airways. A history of difficult intubations in the past or episodes of upper airway obstruction (including snoring or sleep apnea) suggest structural abnormalities that may or may not be evident at the moment. Recent tonsillectomy and adenoidectomy, cleft palate repair, or any prolonged surgical procedure resulting in oral edema or bleeding increase the likelihood of difficulty. Examining facial structure is essential, and inspecting the child’s profile is particularly important because significant abnormalities may not be fully apparent on frontal view alone (Figure 119-4). Certain genetic syndromes are associated with craniofacial anomalies, midline defects, or neuromuscular disorders that may make successful intubation via standard techniques exceptionally difficult. Treacher Collins syndrome (mandibulofacial dysostosis), Goldenhar syndrome (oculoauriculovertebral dysplasia), Down syndrome, Pierre Robin syndrome, and the mucopolysaccharidoses, such as Hurler syndrome and Hunter syndrome, are a few of the syndromes that have characteristic features that suggest the high probability of facing a challenging airway. Isolated micrognathia, macroglossia (glossoptosis), facial clefts, midface hypoplasia, prominent upper incisors or maxillary protrusion, facial asymmetry, a high arched narrow palate, a small mouth, and a short, muscular neck or morbid obesity are features that can interfere with effective bag-mask ventilation or visualization of the larynx. Limited temporomandibular joint or cervical spine mobility may make laryngoscopy and tube placement very difficult. Midface instability or upper airway bleeding, edema, airway or neck masses, and foreign bodies are additional reasons for concern.40




Several classification systems assist with recognition and classification of the adult patient with a difficult airway. Although never validated in pediatrics, they provide a useful framework for assessing infants and children. The Mallampati classification (Figure 119-5) assesses visualization of upper airway structures prior to intubation— particularly the uvula, soft palate, and faucial pillars—as a guide to the likely ease of intubation. Mallampati class 1 allows visualization of the uvula, soft palate, and faucial pillars; in class 2, faucial pillars and soft palate are visualized but the uvula is obstructed by the base of the tongue; in class 3 only the soft palate is visualized; and in class 4 the soft palate is not seen. Difficult intubation is more likely associated with classes 3 and 4. This scale can be used with cooperative children, and an approximate evaluation may be obtained by observing many crying infants and young children.



The Cormack laryngeal view grade score is shown in Figure 119-5, B. Because the Cormack system requires an attempt to visualize the larynx, it is more valuable as a tool for describing difficulty once it has been encountered than for predicting it. The Cormack score is grade 1, full view of vocal cords and glottis; grade 2, partial view of vocal cords and glottis; grade 3, only the epiglottis is seen; and grade 4, the glottis and epiglottis are not visualized. Grades 3 and 4 predict difficult direct laryngoscopy.41 Although these classification systems are helpful in a controlled environment, particularly the preoperative area of a hospital, they are recognized as having limited utility in the emergent situations often encountered in the ICU, and their ability to predict the degree of difficulty with intubation in children is not well established.42


Ability to visualize the faucial pillars, soft palate, and uvula usually predicts an uncomplicated intubation, but this may be difficult to assess in a sick, uncooperative child.43 Children with severe hypoxia, severe hypovolemia, or other causes of hemodynamic instability, such as intracranial hypertension, a full stomach, or some combination of these conditions, present added difficulties that must be considered.


When airway problems are anticipated, the intensivist should approach intubation with a plan specific to the difficulty noted and with a backup strategy in mind.44,45 Extra equipment should be on hand, including a variety of laryngoscope blades, forceps, tubes, bronchoscopes, tracheostomy or cricothyrotomy trays, and additional skilled personnel as needed.46 If sedation is required, agents that can be reversed pharmacologically are desirable and should be titrated slowly to the desired effect. Figure 119-6 shows a modification of the American Society of Anesthesiologist’s difficult airway algorithm and provides an approach to managing the difficult airway.47 A similar plan is necessary at the time of extubation, with serious consideration given to extubation in the operating room or with an airway exchange catheter left in place to facilitate reintubation if necessary.




Process of Intubation


All equipment for intubation must be available prior to the procedure (Figure 119-7). A source of suction and appropriate catheters, oxygen and necessary tubing, ventilation bag, mask, laryngoscope and proper-sized blade with a well-functioning light, endotracheal tubes of the expected size and larger and smaller sizes, airway forceps, stylet, and a means of securing the endotracheal tube should be present at the head of the bed so that the intubator does not need to look away from the patient. A functioning intravenous catheter for drug infusion is essential in all but the most extreme emergencies.



Laryngoscope handles are available in standard adult and pediatric sizes. The smaller diameter of the pediatric handle makes it easier to manipulate, particularly when intubating infants and very young children. Blades of many descriptions are available. The most important characteristic is length. Inexperienced operators often select a blade that is too short, making visualization of the larynx difficult. Excessively long blades make it difficult to avoid pressure on the upper lip and teeth. Straight blades provide good exposure in infants and young children. The slightly curved tip of the Miller blade makes visualization of the larynx possible without actually lifting the epiglottis. The broader blade and bore of the Wis-Hipple blade helps displace soft tissues in the young infant’s oropharynx. The Miller No. 2 blade is especially versatile in a broad age group (i.e., children about 3 to 10 years of age). In older children, use of a curved blade is often works best. If a cuffed endotracheal tube is to be used, a curved Macintosh No. 2 or 3 blade is effective in the majority of patients and may provide more room to manipulate a cuff in the oropharynx.


Selecting the proper tube size (diameter) is important, both to achieve effective mechanical ventilation and to prevent tracheal injury. A variety of formulas are in use, with the most common being that of Cole: Tube size (inner diameter) = (Age [years]/4) + 4. For infants, no formula is very accurate. Table 119-2 gives reasonable guidelines. Individual differences require that the tube size be modified for each child so that the tube passes easily and allows gas to leak around it at roughly 15 to 30 cm H2O pressure but fits snugly enough to allow delivery of adequate mechanical breaths at a given chest compliance.



Traditional teaching has held that use of cuffed endotracheal tubes is not necessary or appropriate in young pediatric patients (younger than 8 years) because the narrow diameter of the trachea at the cricoid ring allows a fairly snug fit without a cuff, and a cuff may make tracheal injury at that level more likely. In addition, the bulk of the cuff usually requires using a tube of 0.5 mm smaller diameter, with the associated increased resistance to gas flow and greater risk of occlusion. Cuffed tubes are routinely recommended for children older than 8 to 10 years because the cricoid ring has been replaced by the triangular opening of the vocal cords as the narrowest point in the airway (see Figure 119-1). In addition, the greater elastic recoil of the lungs and chest wall of older patients may demand higher airway pressures for effective ventilation.


However, cuffed tubes of all sizes are available and may be useful in patients in whom consistent minute ventilation is essential (e.g., in the presence of severely elevated ICP or very reactive pulmonary vasculature) or those requiring relatively high airway pressures. Although data are limited, evidence is growing that cuffed tubes can be used in young children without higher incidence of airway complications.4852 The modern low-pressure, high-volume cuff requires a much lower pressure to obtain a seal than did the endotracheal tube cuffs of the past. When a cuffed tube is used, great care should be taken to inflate it with the “minimum occlusive volume,” the minimum volume required to “just seal” the gas leak around the tube during mechanical inspiration and prevent mucosal ischemia and subsequent tracheal damage. Potential advantages of cuffed tubes include decreased likelihood of multiple intubations to identify the correct size and avoidance of changing the endotracheal tube of a critically unstable patient if lung disease worsens. In addition, absence of a significant leak around the endotracheal tube (ETT) may decrease the likelihood of flow-triggered ventilator autocycling. The ability to occlude the leak also facilitates pulmonary function testing and indirect calorimetry.



Pharmacologic Agents Facilitating Intubation


Although intubation often is possible without use of drugs, the physiologic and psychological benefits of their use usually outweigh the disadvantages.53,54 Analysis of data in the pediatric National Emergency Airway Registry shows that intubation success rate is higher when both sedation and neuromuscular blockade are used.55 This finding is equally true in neonates, in whom sedation and neuromuscular blockade are still commonly not used, with no evidence they are harmful.56 In neonates the predominance of evidence indicates that use of neuromuscular blockade is associated with a lower risk of intracranial hemorrhage and pulmonary airleak.57 Excellent technical airway skills are an absolute prerequisite, however, because loss of control of the airway invites catastrophe. Drugs facilitating intubation are listed in Table 119-3.





Sedative and Analgesic Agents


Most patients benefit from some degree of sedation. Drugs commonly used include intravenous anesthetic agents, anxiolytic agents, and narcotic analgesics. The appropriate choice in a particular patient depends on the child’s hemodynamic status, level of anxiety, and underlying disease process.


Thiopental is a short-acting barbiturate that can provide deep anesthesia, obliterating awareness of the intubation process. It decreases cerebral oxygen consumption and thereby sharply lowers cerebral blood flow (CBF) and ICP. However, it is also a potent myocardial depressant; it decreases peripheral vascular resistance and may precipitate cardiovascular collapse in patients with myocardial dysfunction or hypovolemia. At anesthetic doses (4 to 7 mg/kg), it reliably causes apnea.


Etomidate is another short-acting intravenous anesthetic that causes rapid loss of consciousness (at 0.3 mg/kg) and respiratory depression, although it is less potent than thiopental. It also decreases cerebral oxygen consumption, CBF, and ICP, but without significant detrimental effects on cardiovascular function and with less respiratory depression than thiopental. These characteristics have led to its increased use for emergency intubation.58,59 It has no analgesic properties and may be best combined with a narcotic analgesic. Adverse effects include vomiting, myoclonus, and lowering of the seizure threshold. With continuous infusion for sedation, it can cause adrenal insufficiency, making it inappropriate for long-term use in the ICU.60 Growing evidence suggests it may suppress adrenal function even after a single dose, particularly in patients with sepsis and shock, raising questions about its use in these settings.6170


Ketamine is another potent nonnarcotic analgesic and anesthetic that has been used safely in children in the critical care setting.71,72 It increases heart rate, systemic blood pressure, and cardiac output and is a fairly potent bronchodilator. However, myocardial depression may be apparent after administration to patients with catecholamine depletion. It may be of particular value in patients with status asthmaticus or other reasons for bronchospasm and may have a beneficial effect in sepsis. Spontaneous ventilation is preserved in most patients, but laryngospasm may occur.73 Although in the past it has been considered inappropriate for patients with intracranial hypertension because of evidence that it increases cerebral metabolic rate, blood flow, and ICP, more recent studies indicate that it may be used safely in these patients, although no clear consensus has emerged.74 Emergence delirium and hallucinations occur frequently and may be prolonged and recurrent, particularly in adolescents and young adults. Use of ketamine for a variety of procedures in children has been successful, with little reported difficulty with neuropsychiatric complications, but follow-up in most studies has been short and superficial.7580 Whereas the majority of patients do not suffer severe disturbances, those who do may have severe and prolonged distress. Benzodiazepines or barbiturates may decrease the incidence and severity of such adverse effects and the incidence of vomiting, although the data in children are limited and conflicting.75,81,82


Propofol is an ultra-short-acting agent with rapid onset and offset unless given by continuous infusion. It causes respiratory depression, desaturation, and systemic hypotension secondary to its negative inotropic effects and peripheral venous and arterial vasodilation. Its role in airway management of critically ill children is limited because of these effects. It has gained widespread acceptance as an anesthetic agent in children, however, and has been used extensively for procedural sedation.83,84 Use in the ICU for more than approximately 6 hours is not recommended because of its still unexplained association with metabolic acidosis, cardiovascular collapse and death, propofol syndrome, among pediatric ICU patients.8587 Current labeling warns against its use for prolonged sedation in children.


The benzodiazepines, including diazepam and midazolam, relieve anxiety, produce sedation in most children, and provide amnesia for noxious procedures. They do not relieve pain. They have relatively little hemodynamic effect in most patients and rarely interfere with spontaneous breathing at therapeutic doses. Although they decrease cerebral oxygen consumption, their effect on cerebral metabolism is much less pronounced than that of thiopental. They are best combined with a narcotic analgesic when used for intubation in order to decrease the discomfort and pain associated with laryngoscopy and passage of the tube.


Narcotics commonly used for intensive care include morphine, fentanyl, and some of the ultra-short-acting agents such as remifentanil. They cause respiratory depression in a dose-dependent fashion and increase intracranial blood flow in proportion to the increase in PaCO2. If hypercarbia is prevented, they decrease cerebral metabolic rate and blood flow. In the setting of altered cerebral autoregulation, they may not protect the patient from alterations of CBF.88,89 Morphine causes histamine release and peripheral vasodilation and may precipitate systemic hypotension. Fentanyl is approximately 100 times more potent than morphine but does not release histamine and has little hemodynamic effect, even at anesthetic doses. Large doses given rapidly can cause bradycardia or chest wall rigidity. Remifentanil is a rapid-onset, ultra-short-acting opiate that is even more potent than fentanyl and may have potential benefit in intubation for procedures.

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