Wound Management

Chapter 14 Wound Management




General Principles of Wound Management


Wounds can be considered chronic, such as ulcers, or acute, such as wounds from recent trauma. The goals of wound care are the following:




Wound care begins with management of the patient, then focuses on the general area of injury, and finally addresses the specific wound. The following principles apply to the management of all wounds, regardless of cause, location, or patient presentation2,3:






Wound Healing


Wound healing begins immediately after injury. Vasodilatation produces erythema and edema below the epithelial layer that promotes epithelial cell migration within 24 hours of injury. Fibrin is deposited followed by collagen. Epithelialization closes the wound within 48 to 72 hours if skin margins can be approximated and the wound remains uninfected.4


Adverse conditions can cause skin ulcers and other chronic wounds that heal slowly and are especially at risk of infection. Epithelialization occurs more slowly in patients with the following situations:



Primary closure of a wound is likely if skin edges can be closed and the wound is not infected. This occurs about 4 days after injury and is enhanced by natural wound contracture. A contracture is hazardous in certain hand wounds where it can limit joint movement.


Secondary closure is needed when wound edges will not approximate or the wound is contaminated. It is standard to let the wound granulate and heal more slowly, often with wound packing. These wounds may require skin grafting if the defect exceeds 1 cm in rough diameter.


Scarring is the cosmetic perception of wound healing that occurs over weeks or months. The scar is a dynamic process of collagen synthesis and lysis. In balance, this “creative destruction” of scar tissue produces a flat scar. Lack of collagen in genetic conditions can cause keloids and hypertrophic scarring; lack of collagen synthesis occurs from wound ischemia, steroid use, and other factors that reduce scarring yet also reduce skin tensile strength.5




Treatment Considerations




Skin Antisepsis and Cleanser


Reducing skin contamination is usually done with chlorhexidine (Hibiclens), a 10% povidone-iodine (Betadine) solution, or hydrogen peroxide. Any benefit may be offset if skin antiseptics spill into the wound because they impair wound defenses, damage delicate tissues, and delay healing. A dilute (1%) povidone-iodine solution is not as toxic to tissue but should be reserved for infection-prone wounds.10






Tetanus Immunization


Tetanus is caused by Clostridium tetani, a gram-positive anaerobic bacillus. Because C. tetani forms spores, this organism is highly resistant to measures taken against it. C. tetani is present in soil, in garden moss, on farms, and anywhere animal and human excreta can be found. Bacteria enter the circulation through an open wound and attach to cells within the central nervous system. The usual incubation period is 2 days to 2 weeks. However, spores can lie dormant in tissue for years, so scrupulous wound cleansing is crucial. As long as immunizations are current, tetanus is a 100% avoidable condition.


Postexposure immunizations should be given only when needed. Individuals can become sensitized by frequent vaccination, and subsequent injections can cause several days of painful swelling. This type of reaction is the usual source of “tetanus allergy” reported by some patients. Recommendations for tetanus immunization are based on current guidelines from the Centers for Disease Control and Prevention (CDC), which advises that the tetanus vaccine also should contain diphtheria toxin. This combination, dT(Td), is given as a single 0.5-mL intramuscular dose.12



Tetanus vaccination routinely begins in childhood. Properly vaccinated children receive tetanus, diphtheria, and pertussis vaccines at ages 2, 4, 6, and 18 months, as well as at 4 and 6 years of age. A booster is provided at age 16 years.


To remain vaccinated, adults should have received the initial tetanus series and be revaccinated a minimum of every 10 years.


If an adult presents to the ED with a wound that has minimal contamination, assure that they have received both the initial tetanus series as well as revaccination within the past 10 years. If it has been longer than 10 years, they should receive dT(Td) as part of their ED visit.


If an adult presents to the ED with a wound that is grossly contaminated (tetanus prone), assure that they have received both the initial tetanus series as well as revaccination within the past 5 years. If it has been longer than 5 years, they should receive dT(Td) as part of their ED visit.


Ideally, for patients whose immunization status is outdated, unclear, or unknown, tetanus prophylaxis should be given as soon after the wound is sustained as possible, although, immunization will be effective if given up to 72 hours after the wound occurred. Immunization may be considered after 72 hours, but there is a risk that tetanus may have become active within the central nervous system at this point and diligent patient follow up should be considered.


If the patient has not received an initial tetanus series (or has only received one of the series), they should be started on a regimen with 0.5 mL of dT(Td) in the ED. If the patient has a grossly contaminated wound (tetanus prone), simultaneous administration of 250 units of intramuscular antitoxin is recommended.


Patients with partial immunity, from two or more previous tetanus injections, are considered sufficiently immune. The CDC recommends a booster of 0.5 mL dT(Td), even for patients with grossly contaminated (tetanus prone) wounds.


Patients over the age of 6 years who have not completed an initial immunization series should be referred to their primary care providers or local health department for a second dT(Td) dose (0.5 mL intramuscularly) in 4 to 6 weeks and a third injection in 6 to 12 months.11,12 New CDC recommendations suggest the first of these doses should be the tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine.13


In 2010, the CDC recommended expanded use of Tdap. A single Tdap dose is recommended for adults aged 19 to 64 years and children aged 11 to 18 years who have completed the recommended childhood DTP/DTaP vaccination series.13




Prophylactic Antibiotics


Antibiotics are not indicated for simple open wounds in healthy patients because the wounds rarely become infected. However, they are indicated for wounds with devitalized tissue, contamination with soil or feces, contact with saliva (bites), or patients with lymphoma. Antibiotics should always be considered an adjunct to debridement and irrigation rather than a substitute.11 The selection of a prophylactic antibiotic depends on many factors, including the location of the wound, the type of pathogens usually encountered with a particular injury, and the fact that most contaminated wounds contain a wide variety of organisms. Little evidence exists to support the routine application of topical antibiotics on simple wounds.4



Anesthesia


Routes of anesthesia administration for wound closure include topical, wound infiltration, regional blocks, and intravenous procedural sedation. The methods selected depend on the patient, the wound, and its location.




Anesthetic Agents


The most common anesthetic for local infiltration or regional use is lidocaine, primarily because of its low tissue toxicity. Additionally, lidocaine has a short duration of action, which is desirable for repairs of areas such as the mouth or lip, where recovery of sensation reduces the incidence of unintentional biting of the wound. Likewise, prompt return of sensation to a finger prevents further injury as the patient begins to use the hand.


One disadvantage of lidocaine is the pain associated with injection. Warming the solution to 37° C (98.6° F) can minimize this effect. Sodium bicarbonate also reduces the pain associated with lidocaine injection. Buffer lidocaine by adding one part 8.4% sodium bicarbonate (1 mEq/mL) to 10 parts 1% lidocaine (i.e., add 1 mL of sodium bicarbonate to 10 mL of lidocaine). However, this mixture reduces the shelf life of lidocaine from 3 years to a few days, after which the solution will precipitate in the bottle.12


Preparations of lidocaine with epinephrine are also available. Epinephrine increases the duration of anesthesia and decreases bleeding. Use of this combination is contraindicated in heavily contaminated wounds or those with a tentative blood supply such as avulsions. Adverse effects of epinephrine include an increased rate of infection and ischemia when lidocaine with epinephrine is injected into the ear, tip of the nose, digits, or penis.


Another anesthetic agent used for infiltration is bupivacaine (Marcaine, Sensorcaine). The effects of this drug last four times longer than lidocaine. This makes bupivacaine ideal for situations in which wound closure will require longer than 2 hours or when prolonged local anesthesia is desirable.



Anesthetic Allergy


Patients frequently report an allergy to lidocaine; however, true allergy to injected anesthetics is uncommon.12 Many reported allergies are actually adverse reactions such as hyperventilation, vasovagal syncope or light-headedness, cardiovascular stimulation from epinephrine, and various idiosyncratic reactions to the injury and subsequent wound repair. Contact dermatitis, caused by topical local anesthetics, also has been reported. This type of reaction is not immunoglobulin E–mediated and poses little risk. If a true allergy is suspected, an anesthetic from a different chemical class can be used. Sterile saline infiltration, guided imagery, and hypnosis are nonpharmacological options. If local anesthesia is not possible, needleless wound closure techniques such as tying hair on the scalp or applying adhesive closure strips (e.g., Steri-Strips) or wound glue should be considered.



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Aug 9, 2016 | Posted by in EMERGENCY MEDICINE | Comments Off on Wound Management

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