Von willebrand disease




J Von willebrand disease




Definition


von Willebrand disease (vWD) has traditionally remained the most common inherited coagulation diathesis. von Willebrand factor (vWF) VIII is a heterogeneous multinumeric glycoprotein that serves two main functions: to facilitate platelet adhesion and to behave as a plasma carrier for factor VIII:C of the coagulation cascade. vWF is synthesized in the endothelial cells and in megakaryocytes. An acquired form of vWD:VIII is seen with lymphomyeloproliferative or immunologic disease states secondary to antibodies against vWF:VIII.

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Dec 2, 2016 | Posted by in ANESTHESIA | Comments Off on Von willebrand disease

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