RHABDOMYOLYSIS

Conditions associated with rhabdomyolysis are listed in Table 53-1.


images Comatose patients are at risk for rhabdomyolysis due to prolonged immobilization with continual pressure on gravity-dependent parts of the body.


TABLE 53-1 Common Conditions Associated with Rhabdomyolysis in Adults


image


PATHOPHYSIOLOGY


images Skeletal muscle injury results in cellular death with resultant leakage of previously intracellular contents into the vasculature.


images Common cellular agents that leak into the circulation include myoglobin, creatinine kinase, aldolase, lactate dehydrogenase, potassium, and aspartate aminotransferase.


images Disruption of the sodium/potassium/ATPase and calcium transport results in increased intracellular calcium which, ultimately triggers cellular death.


CLINICAL FEATURES


images A number of clinical histories should raise the clinician’s suspicion for this syndrome, the most common of which follow.


images Prolonged immobilization from any cause may lead to rhabdomyolysis, especially in association with drug intoxication such as that caused by narcotics, sedative-hypnotic medications, or ethanol consumption.


images Drug intoxication with sympathomimetics may lead to rhabdomyolysis without immobilization, including cocaine, amphetamine, or phencyclidine (PCP) abuse, or antihistamine use.


images Excessive muscular activity or strenuous exercise may lead to rhabdomyolysis; see Table 53-1 for common causes.


images Injuries that can cause a compartment syndrome or prolonged muscular compression such as crush injuries, heat stroke, and electrical injuries may lead to rhabdomyolysis.


images Certain diseases or disease states are associated with rhabdomyolysis such as polymyositis, dermatomyositis, and neuroleptic malignant syndrome.


images Common complaints include muscle ache/stiffness, malaise, muscle tenderness (especially thigh or calf muscle), and dark-colored urine. However, these signs and symptoms are neither sensitive nor specific.


DIAGNOSIS AND DIFFERENTIAL


images Diagnosis is made by measuring the serum creatinine kinase (CK). An elevation of at least five times the upper limit of normal, with the exclusion of cardiac etiologies is diagnostic of rhabdomyolysis.


images The serum CK rises 2 to 12 hours after the initial injury, and peaks 1 to 3 days after the injury resolves.


images Myoglobinuria can be detected once plasma myoglobin concentration exceeds 1.5 milligrams/dL.


images The presence of heme on the urine dipstick without observing blood cells on microscopy is a diagnostic clue.


images Obtain CK levels and basic metabolic studies for all patients suspected of having rhabdomyolysis.


EMERGENCY DEPARTMENT CARE AND DISPOSITION


images The primary focus is intravenous hydration with crystalloids. Typically, several liters of normal saline are given; use caution in patients who cannot tolerate rapid infusions of fluid.


images Urinary alkalinization is often performed, but has not been clearly demonstrated to improve outcome.


images Electrolytes should be monitored carefully as therapy is given in severe cases.


images Phosphorus and should only be treated when above 7 milligrams/dL or below 1 milligram/dL.


images Hyperkalemia requires aggressive therapy (see Chapter 6); avoid agents that would dehydrate the patient.


images Monitor urine output closely.


images Avoid potentially nephrotoxic drugs, if possible.


images Hydrate patients with mild rhabdomyolysis without comorbidities in the emergency department, after which they may be discharged.


images Admit patients with acute kidney injury, significant comorbid conditions, or marked elevations in the CK.


images Complications include acute kidney injury, hyper-calcemia (late), hyperphosphatemia (early), hypo-phosphatemia (late), hyperkalemia, hyperuricemia, hypocalcemia, and disseminated intravascular coagulation.


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Feb 13, 2017 | Posted by in EMERGENCY MEDICINE | Comments Off on RHABDOMYOLYSIS

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