Chapter 19
Preoperative Evaluation and Preparation of the Patient
• Optimize patient care, satisfaction, comfort, and convenience.
• Minimize perioperative morbidity and mortality by accurately assessing factors that influence the risk of anesthesia or might alter the planned anesthetic technique.
• Minimize surgical delays or preventable cancellations on the day of surgery.
• Determine appropriate postoperative disposition of the patient (i.e., given the patient’s status, whether the procedure is best performed on an ambulatory, inpatient, or intensive care basis).
• Evaluate the patient’s overall health status, determining which if any preoperative investigations and specialty consultations are required.
• Formulate a plan for the most appropriate perianesthetic care and postoperative supportive patient care.
• Communicate patient management issues effectively among care providers.
• Educate patient regarding surgery, anesthesia, and expected intra- and postoperative care, including postoperative pain treatments, to reduce patient anxiety and increase patient satisfaction.
• Ensure time-efficient and cost-effective patient evaluation.
Important strategies for achieving high-quality, cost-effective patient evaluation include the following1:
• Educating the practitioner (e.g., regarding the cost of diagnostic tests) and thereby modifying practice patterns
• Developing and implementing evidence-based practice guidelines
• Using clinical pathways (interdepartmental teamwork required)
• Disseminating information regarding protocols, thereby avoiding duplication of services
• Performing economic analyses of services, including cost-effectiveness, and cost-benefit studies
• Rendering efficient resource management
Preanesthesia Assessment Clinic
The preanesthesia assessment clinic has emerged as the most effective means of providing convenient “one-stop shopping” designed to (1) permit patient registration, (2) obtain a medical history and perform a physical examination, (3) promote patient teaching, (4) meet or schedule appointments with medical consultants, and (5) complete any required preoperative diagnostic testing. Successful preanesthesia assessment clinics have realized a reduction in patient anxiety, direct cost, last-minute surgical cancellations, overall length of hospitalization after surgery, and diagnostic testing, as well as improvement in patient education and a shift from inpatient to outpatient surgery status.2 The preanesthesia assessment clinic allows patients scheduled for elective surgery to be evaluated and their condition optimized sufficiently in advance of the surgery.
Timing of Patient Assessment
To allow ample time for necessary risk assessment, preoperative testing, and specialty consultations, ideal preoperative assessment for surgery and anesthesia should take place well in advance of the proposed surgery. Patients with complex medical conditions should be evaluated at least 1 week before the scheduled procedure. Because of the present economic realities, patients undergoing more complex procedures and those who have complicated medical conditions (Box 19-1)3 are frequently not admitted to the hospital before the day of surgery. Preoperative evaluation on the day of surgery can result in last-minute discoveries (e.g., of inappropriate fasting, suspected difficult airway, preexisting medical condition) that may result in surgical delay or cancellation. The timing of the preanesthesia assessment does not appear to influence outcome of anesthesia.4 In one study, no difference in the cancellation rate for ambulatory patients was observed between groups seen within 24 hours and groups seen within 1 to 30 days of the scheduled surgery.5 Governmental requirements may mandate that the preanesthesia evaluation be completed and documented by a qualified anesthesia practitioner within 48 hours prior to surgery.6 This focused evaluation must be performed by a practitioner qualified to administer anesthesia.
Chart Review
Patient Chart or Electronic Medical Record
A preanesthesia questionnaire is included on the patient’s chart (Figure 19-1). This questionnaire should be part of the admission paperwork to be completed by the patient or the patient’s caregiver and consists of a concise checklist regarding the patient’s health history and medical care. When properly completed and readily available on the chart, the preanesthesia questionnaire enables the anesthesia provider’s visit with the patient to be accomplished more efficiently. Interview questions and physical assessment are appropriately directed toward abnormal findings and areas of concern.
Patient Interview
The preoperative interview may be conducted in person or by telephone. The in-person patient interview is preferred, but for patients who are unable to visit the hospital setting (e.g., who live far from the hospital or have transportation constraints), an opportunity to participate in a telephone interview should be made available. Regardless of the location or approach used, the interview promotes a trusting relationship between the patient and anesthesia provider. When the interview is performed in a caring and unhurried manner, the patient’s degree of trust and confidence in anesthesia care is enhanced. Furthermore, compliance with perioperative instructions is increased when the patient is treated with respect; an example of such respect is using the surname (Mr. Smith, Mrs. Jones) unless instructed differently by the patient.
Because the preoperative interview is a private interaction between the patient and the anesthesia provider, a tactful request that visitors remain outside the interview area, unless the patient wishes family members to be present, will be necessary. Otherwise, the patient may not volunteer confidential health information, such as a history of substance abuse or sexual history. In certain situations, however, assistance from a family member or caregiver is required. The health history may be provided, for example, by the parent of a pediatric patient or by an interpreter for a patient with cognitive or language barriers.
The patient interview is designed to achieve specific objectives (Box 19-2).7 The interview process, along with patient education, yields beneficial consequences of reduced patient anxiety and increased patient satisfaction. A valuable step in preparing the patient or responsible caregivers (e.g., family members, legal guardian) for the scheduled surgery includes an educational process during which the staff counsels the patient concerning fundamental perioperative issues (Box 19-3).7 Reinforcing information to the patient verbally and in writing is essential to gaining patient compliance. Coordinating the patient’s visit to the preanesthesia assessment clinic to include educational time is ideal for the patient.
Drug History
A preoperative drug history provides an excellent guide for the direction and depth of the patient interview and assessment. Drug dosages, schedules, and durations of treatment are reviewed and the patient questioned about the purpose and effectiveness of these medications. An interview with a patient receiving β-adrenergic blockers, for example, can focus in greater detail on the cardiovascular system. Patients on medications for hypertension or angina pectoris require further investigation and possibly specialty consultation if they have not been recently evaluated.
Adverse Drug Effects and Interactions
During the preoperative evaluation, current drug therapy must be carefully reviewed for side effects and potential interactions with anesthetic agents. Table 19-1 lists selected drugs and their potential anesthetic interactions.4,8–17 One drug-management strategy is to discontinue particular drugs preoperatively in the hope of reducing the potential for adverse interactions. The therapeutic benefits of these drugs are weighed against the risks of abrupt discontinuation. Abrupt discontinuation of long-standing medication may lead to the development of undesirable withdrawal symptoms. With occasional exceptions, the majority of medications are continued preoperatively. Should a decision be made to withhold a particular drug before surgery, sufficient time should be allowed for metabolic clearance (ideally three to five half-lives).8
TABLE 19-1
Potential Drug Interactions Affecting Perianesthesia Care
Data from Doak GJ. Discontinuing drugs before surgery. Can J Anaesth. 1997;44(5 Pt2):R112-R123; Pass SE, Simpson RW. Discontinuation and reinstitution of medications during the perioperative period. Am J Health Syst Pharm. 2004;61(9):899-912; Schirmer U, Schurmann W. Preoperative administration of angiotensin-converting enzyme inhibitors. Anaesthesist. 2007;56(6):557-561; Baillard C. Preoperative management of chronic medications. Ann Fr Anesth Reanim. 2005(11-12);24:1360-1374; Huyse FJ, et al. Psychotropic drugs and the perioperative period: a proposal for a guideline in elective surgery. Psychosomatics. 2006(1);47:8-22; Fleischmann KE, et al. 2009 ACCF/AHA focused update on perioperative beta blockade: a report of the American College of Cardiology Foundation/American Heart Association task force on practice guidelines. Circulation. 2009;120(21):2123-2151; Hoeks SE, Poldermans D. European Society of Cardiology 2009 guidelines for preoperative cardiac risk assessment and perioperative cardiac management in noncardiac surgery: key messages for clinical practice. Pol Arch Med Wewn. 2010;120(7-8):294-299; Lieb K, Selim M. Preoperative evaluation of patients with neurological disease. Semin Neurol. 2008; 28(5):603-610; De Hert S, et al. Preoperative evaluation of the adult patient undergoing non-cardiac surgery: guidelines from the European Society of Anaesthesiology. Eur J Anaesthesiol. 2011;28(10):684-722; White CM, et al. Effect of preoperative angiotensin converting enzyme inhibitor or angiotensin receptor blocker use on the frequency of atrial fibrillation after cardiac surgery: a cohort study from the atrial fibrillation suppression trials II and III. Eur J Cardiothorac Surg. 2007;31(5):817-820; Whinney C: Perioperative medication management: general principles and practical applications. Cleve Clin J Med. 2009;76(suppl 4): S126-S132.
Latex Sensitivity
Patient sensitivity to latex products has recently been identified as a frequent basis of allergic reaction. Up to 20% of intraoperative anaphylactic reactions have been attributed to latex sensitivity.18 The preoperative questioning of patients should include inquiry regarding specific latex sensitivity or allergy. Patients at increased risk for latex sensitivity should be cared for in a no-latex setting and scheduled as the first case of the day to reduce the likelihood of aeroallergen latex exposure. The diagnosis of latex allergy is based on the findings of the history and physical examination and if necessary, in vivo (skin-prick test is the most sensitive) and in vitro testing. Preoperative testing is indicated only when there is a family history of reactions or when patients report experiencing symptoms such as a rash, swelling, or wheezing when exposed to latex.19 Patients at high risk for latex sensitivity include those with a history of the following18:
• Chronic exposure to latex-based products (e.g., industrial workers using protective gear; occupational exposure to latex)
• Spina bifida, urologic reconstructive surgery
• Repeated surgical procedures (more than nine)
• Intolerance to latex-based products (e.g., balloons, rubber gloves, condoms, dental dams, rubber urethral catheters)
• Allergy to food and tropical fruits (e.g., avocado, banana, buckwheat, celery, chestnut, kiwi, mango, papaya, passion fruit, peach)
• Intraoperative anaphylaxis of uncertain cause
• Healthcare professionals, especially with a history of atopy or severe dermatitis, hand eczema
Social History
• Approximately 22.6 million Americans aged 12 years of age or older (9%) were classified as illicit drug users in 2010.20
• Nearly one quarter of all deaths (75,000 annually)21 in the United States are caused by addictive substances.22
• The economic burden of addiction (e.g., healthcare expenditures, missed work, crime) is estimated at more than $400 billion annually.22
Tobacco Use
• One in five deaths in the United States is related to smoking. Cigarette smoking is the leading cause of preventable premature death in the United States (approximately 443,000 premature deaths annually).23
• In 2010, 27% (70 million) of Americans aged 12 or older smoked.20
• Teen smoking rates have declined from 15.2% in 2002 to 10.7% in 2010.20
• Smokers die 14 years earlier than nonsmokers.24
• Exposure to secondhand smoke causes 3400 deaths a year from lung cancer and 46,000 deaths from coronary heart disease; 776 newborns a year die from sudden infant death syndrome attributed to secondhand smoke.25
The inhaled components of tobacco smoke lead to multiple pathophysiologic changes within the body. Nicotine and carbon monoxide are just two of the more than 6000 noxious components that have been identified in tobacco smoke.26 Nicotine, a toxic alkaloid, produces ganglionic stimulant effects and is the tobacco component that affects the cardiovascular system.27 Acute side effects of nicotine include increased heart rate, blood pressure, myocardial contraction, myocardial oxygen consumption, myocardial excitement, and peripheral vascular resistance. Net effects of nicotine’s cardiovascular influence include impaired coronary blood flow and an adverse myocardial oxygen supply/demand ratio.28 Carbon monoxide readily occupies the oxygen-binding sites of hemoglobin (approximately 250 to 300 times greater affinity for hemoglobin than oxygen).29 Oxygen transport to the tissues and resultant oxygen use is thereby drastically reduced. In the heavy smoker, carboxyhemoglobin may be as high as 15%, which effectively reduces the patient’s oxyhemoglobin percentage accordingly. The adverse effects of nicotine on the cardiovascular system and carbon monoxide on oxygen-carrying capacity are short lived (half-life of nicotine is 40 to 60 minutes30; half-life of carbon monoxide if room air is breathed is 130 to 190 minutes).31
Patients should be instructed to stop smoking at least 12 to 48 hours before surgery. Short-term (e.g., 12 hours) preoperative abstinence from tobacco smoke reduces the deleterious effects of nicotine and carbon monoxide on cardiopulmonary function.32 Smoking cessation for even 1 night before surgery reduces heart rate, blood pressure, and circulating catecholamine levels33 and allows carboxyhemoglobin values to return to normal levels.34
Patients who smoke have a higher incidence (a nearly sixfold increase35) of postoperative pulmonary complications (pneumonia and atelectasis).36 A smoking history of more than 20 pack years equates to an increased risk of perioperative complications.37 Smoking cessation of less than 4 weeks does not reduce the risk of postoperative respiratory complication.4,38 Longer periods of smoking cessation (8 weeks or longer) result in a marked improvement in pulmonary mechanics (e.g., enhanced ciliary function, decreased mucous secretion and small airway obstruction, and enhanced immune function).39 Patients who stopped smoking less than 2 months before surgery had nearly four times the pulmonary complications (e.g., purulent sputum, secretion retention, bronchospasm, pleural effusion, pneumothorax, segmental pulmonary collapse, pneumonia) of those who abstained from smoking for longer than 2 months.40 However, even short-term smoking cessation is effective in reducing postoperative complications when compared with patients who continued to smoke up until the time of surgery.39 A reduction in postoperative wound-related complications occurs in patients who stop smoking preoperatively.41 Patients who smoke should be advised to quit even immediately prior to surgery, without fear of worsening pulmonary outcomes or increasing psychological stress as a result of acute abstinence.42 Effective interventions, including behavioral support and nicotine replacement therapy, should be made available to smokers considering abstinence at this time.43
The influence of environmental tobacco smoke (also known as secondhand or passive smoke) on children has been found to produce disturbing respiratory consequences, including increased reactive airway disease, abnormal results of pulmonary function tests, and increased respiratory tract infections.44,45 The perioperative complications in children exposed to smoke include laryngospasm, coughing on induction or emergence, breath holding, postoperative oxyhemoglobin desaturation, and hypersecretion.46
Alcohol Intake
An estimated 14 million Americans are dependent on alcohol, with 105,000 deaths annually attributed to alcohol abuse.47 Perioperative complications, such as arrhythmias, infection, and alcohol withdrawal syndrome, are increased two- to fivefold in chronic excessive alcohol users.48 Postoperative complications can by reduced with 4 or more weeks of abstinence prior to surgery.49 Information regarding the type and amount of alcohol regularly consumed and the frequency of consumption is important in the evaluation for anesthesia and surgery. Often an accurate assessment of a patient’s alcohol intake may be difficult to obtain. The Alcohol Use Disorders Identification Test (AUDIT), a self-reporting questionnaire designed to identify problem drinkers, can be incorporated into the preoperative interview of suspected problem drinkers.50 A less confrontational and a reliable approach to evaluating a patient’s potential for an alcohol problem uses the mnemonic CAGE, which refers to the following four questions51:
1. Do you feel you should cut down on your alcohol consumption?
2. Have people annoyed you by criticizing your drinking habits?
3. Have you felt guilty about your drinking?
4. Have you ever had a drink first thing in the morning to steady your nerves or get rid of a hangover (eye-opener)?
A patient reporting more than two positive responses is at high risk for alcoholism and an increased likelihood of experiencing withdrawal symptoms.52 Both AUDIT and CAGE have been shown to be effective in identifying the abusive alcohol consumer.53
In the heavy drinker, it is important to determine whether the patient has experienced seizures, abrupt withdrawal syndrome, or delirium tremens as a consequence of alcohol abuse. Clinical signs suggestive of alcohol withdrawal include increased hand tremors, autonomic hyperactivity (e.g., sweating, tachycardia, systolic hypertension), insomnia, anxiety, restlessness, nausea or vomiting, transient hallucinations (visual, tactile, or auditory), psychomotor agitation, and grand mal seizures.52
Chronic alcohol abuse results in the development of tolerance, physical dependence, and multisystem organ dysfunction. Tolerance to alcohol is evidenced by a resistance or cross-tolerance to other central nervous system (CNS) depressants. For example, the anesthetic requirement of hypnotics, opioids, and inhalation agents is increased in the chronic alcoholic; however, exaggerated responses to anesthetic agents are likely during periods of acute intoxication or advanced alcoholism. This effect is attributed to the additive depressant effects of alcohol and anesthetic agents. Enzymatic function and plasma albumin concentrations may also be reduced in patients with alcoholic hepatic insufficiency. As a result, greater circulating concentrations of unbound intravenous agents may result in an exaggerated and prolonged drug effect.54 This enhanced drug response has not been shown to occur with propofol in patients with moderate liver cirrhosis.55
An insidious progression of multisystem organ dysfunction is also characteristic of long-term alcohol abuse. Numerous illnesses are attributable to the toxic adverse effects of advanced alcoholism on overall health and nutrition. Predictably, postoperative morbidity and mortality rates are increased in alcoholic patients as a result of poor wound healing, infection, bleeding, pneumonia, and further hepatic deterioration.56,57
Illicit Drug Use
Use of illicit drugs (e.g., cocaine, cannabis, “crack,” lysergic acid diethylamide-25 [LSD], amphetamines, heroin, hallucinogens, inhalants, prescription-type psychotherapeutics used nonmedically) is a significant healthcare issue in the United States. The most popular recreational drugs continue to be cocaine and marijuana. Monthly drug abuse among Americans include 17 million marijuana users, 7 million prescription-type psychotherapeutic nonmedical drug users, 1.5 million cocaine users, 1.2 million hallucinogen users, and 731,000 methamphetamine users in 2010.20 Americans use 80% of all opioids available in the world.58 The use of these substances increases the risk for adverse consequences and drug interactions during anesthesia. An accurate illicit drug history is often difficult to obtain because of the patient’s fear of legal reprisal or refusal to believe a drug problem exists. During the physical examination, the anesthesia provider should look for signs that indicate illicit drug use by the patient. A diagnosis of recent or continuing drug abuse should be suspected in patients exhibiting the following on physical examination59:
• Evidence of drug injection (e.g., track marks or scarring), thrombotic veins, phlebitis, tattoos (may be used to mask the sites), ablation of venous return leading to unilateral edema of the nondominant hand, subcutaneous skin abscesses
• Ophthalmologic changes, such as pupillary constriction from opioid use, pupillary dilation with amphetamine use, nystagmus from phencyclidine (PCP) use
• Lymphadenopathy secondary to nonspecific activation of the immune system as a result of repeated injections of impurities
• Malnourishment as a result of amphetamine abuse (opioid users tend to be well nourished)
• Poor dental care and bruxism (involuntary grinding and clenching of teeth) from amphetamine use
Primary concerns for the anesthesia provider are the likelihood of the patient exhibiting acute abuse or possible withdrawal syndrome.60 Signs and symptoms of acute abuse of the more common substances are listed in Box 19-4.59,60 Elective surgery should be delayed or canceled in patients suspected of being under the influence of an illicit drug until further patient evaluation can be performed. Suspicion of acute substance abuse should be followed up with a urine screen for drug identification. Abstinence syndrome typically exhibits increased sympathetic and parasympathetic responses resulting in hypertension, tachycardia, abdominal cramping and diarrhea, tremors, anxiety, irritability, lacrimation, mydriasis, algid sweat, and yawning.61
Synthetic Androgens
Anabolic steroids are self-administered in an attempt to increase muscle mass, strength, and growth, and improve athletic performance, but such actions can result in hepatic and endocrine system dysfunction. Risks associated with long-term androgen steroid supplementation include impaired liver function, cholestatic jaundice, hepatic adenocarcinoma, peliosis hepatis, myocardial infarction (MI), atherosclerosis, hypercoagulopathy, stroke, hypertension, dyslipidemia, and psychiatric and behavioral disturbances in susceptible patients.62–65 The hepatotoxic effects have important implications for the anesthetic management of a chronic steroid abuser, particularly with agents metabolized by the liver, and such patients should undergo preoperative liver function testing.
Herbal Dietary Supplements
Patients should be questioned regarding their use of nonprescription herbal medications to determine the herb’s name, the duration of herbal therapy, and the dose taken. If patients are in doubt as to the herbal medications they are taking, they should be encouraged to bring the herbal products with them to their preoperative workup. Certain herbal products are known to influence blood clotting, affect blood glucose levels, produce CNS stimulation or depression, or interact with psychotropic drugs (Table 19-2).66,67
TABLE 19-2
PT-PTT, Prothrombin time–partial thromboplastin time.
Modified from Ang-Lee MK, et al. Herbal medicines and perioperative care. JAMA. 2001;286:208-216; Kaye AD, et al. Perioperative anesthesia clinical considerations of alternative medicines. Anesthesiol Clin North America. 2004;22:125-139; Hogg LA, Foo L. Management of patients taking herbal medicines in the perioperative period: a survey of practice and policies within anaesthetic departments in the United Kingdom. Eur J Anaesthesiol. 2010;27(1):11-5.