Glutamine Supplementation in Critically Ill Patients


Drug

Indications

Contraindications

Side effects

Dose

Note

Glutamine (alanyl-glutamine and glycine-glutamine)

Critically ill patients (intensive care unit patients, burns, surgical patients)

Bone marrow transplant

Weight loss in patients with AIDS

Cirrhosis or severe liver disease with hepatic encephalopathy

Metabolic acidosis

Renal insufficiency (creatinine clearance <25 mL/min)

Monosodium glutamate sensitivity

Seizures

Increased frequency of high urea levels (>50 mmol/L)

0.35 g/kg intravenously plus

30 g per day enterally

In critically ill patients it increases mortality


AIDS acquired immunodeficiency syndrome





References



1.

Cartin-Ceba R, Afessa B, Gajic O (2007) Low baseline serum creatinine concentration predicts mortality in critically ill patients independent of body mass index. Crit Care Med 35(10):2420–2423CrossRefPubMed


2.

Robinson MK, Mogensen KM, Casey JD, McKane CK, Moromizato T, Rawn JD, Christopher KB (2015) The relationship among obesity, nutritional status, and mortality in the critically ill. Crit Care Med 43:87–100 [Epub ahead of print]


3.

Desai SV, McClave SA, Rice TW (2014) Nutrition in the ICU: an evidence-based approach. Chest 145(5):1148–1157CrossRefPubMed


4.

Wischmeyer PE (2007) Glutamine: mode of action in critical illness. Crit Care Med 35:S541–S544CrossRefPubMed


5.

Rodas PC, Rooyackers O, Hebert C, Norberg Å, Wernerman J (2012) Glutamine and glutathione at ICU admission in relation to outcome. Clin Sci (Lond) 122:591–597CrossRef

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May 9, 2017 | Posted by in CRITICAL CARE | Comments Off on Glutamine Supplementation in Critically Ill Patients

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