Cystic fibrosis affects multiple organs. Management is thus a multidisciplinary effort that may involve surgery (general, cardiothoracic, or transplant), endocrinology, otolaryngology, pulmonology, cardiology, and gastroenterology. Most often the patient with cystic fibrosis is treated primarily by a pulmonologist because of the prevalence of pulmonary symptoms. The viscous secretions commonly seen in the patient with cystic fibrosis create a persistent, rich growth medium for infectious organisms, such as Haemophilus influenza, Klebsiella pneumoniae, Escherichia coli, and Staphylococcus aureus. The patient typically experiences recurrent bouts of respiratory/pulmonary infections that are treated with antibiotics. They are usually very well educated about the disease, even at a young age, and receive respiratory treatments every day. One goal of the treatments is to dramatically reduce the viscosity of the secretions and facilitate expectoration of the mucus. Daily chest physiotherapy and postural drainage are often required to help facilitate expectoration of the mucus.