Withholding and withdrawing life support in the intensive care unit




* Adapted by Medical Triage Policy, Yale–New Haven Hospital.


example, when the demand for ICU beds exceeds capacity, physicians may have to deny admission to patients who might benefit.3 Similarly, physicians may not be able to provide requested care because desired outcomes cannot be achieved, which, by definition, limits options.4 Most end-of-life decisions in the ICU, however, are less constrained, leaving patients or surrogates with treatment options to consider.


Triage


With increasing frequency, physicians are forced to choose among multiple patients vying for a limited number of ICU beds. Contributing factors include growth in the critically ill population, increasing recognition of better outcomes associated with ICU admission, and concerns about bioterrorism and pandemics. As a result, ICU administrators and physicians are obligated to implement effective, fair triage plans to optimize bed use.

By definition, triage implies that patients who might benefit from the ICU may be denied admission. The decision to deny admission could bring harm, including death, to the patient. Hospitals should seek to avoid the need to triage by investing sufficiently in resources to meet demand by ensuring a sufficient supply of qualified staff, beds, and equipment. In addition, steps should be taken to safely decrease ICU length of stay by promoting good practices, such as timely weaning from mechanical ventilation, making timely end-of-life decisions, and encouraging efficient throughput by transferring patients out of the ICU as soon as they are eligible. Institutions should maximize their ability to care for patients outside the unit, for example by increasing skills and staffing of non-ICU personnel. Denying ICU admission should not be equated with the decision to forgo life support, although sometimes that may be the implication.

The goal of triage is to maximize utilization of the ICU by patients most likely to benefit (Table 17.1). In choosing among patients, two key factors to consider are severity of illness and potential to benefit. Patients requiring life support technology such as intubation and mechanical ventilation, continuous renal replacement therapy, or left ventricular support devices generally have a more compelling need for ICU care than those requiring monitoring alone. At the same time, factors such as severity of the acute illness and chronic comorbidities strongly influence the likelihood of benefit. Patients who are moribund and unlikely to survive despite aggressive care are often less likely to benefit than those that are less ill. The same holds for patients with severe underlying illnesses, like advanced cancer, in whom the prognosis is likely to be poor regardless of the intervention provided.

Basic principles of fairness should govern triage. It is inappropriate to discriminate on the basis of race, gender, sexual orientation, ability to pay, or political connections. Whether to discriminate on the basis of age or functional status is controversial. Objective scoring systems should be used to maximize fairness. To minimize conflicts of interest, triage responsibility should be delegated to physicians not directly involved in patient care. Physicians responsible for triage require institutional support to support their authority while the hospital administration, attorneys, and ethics committee should be enlisted to provide oversight and guidance. Finally, when admission is denied, decisions must be made to determine if life saving efforts will be attempted outside the ICU or whether the focus should shift to palliation alone.

Futility


In the context of decision-making, futility refers to care that cannot achieve a desired end point.4 How often futile care is requested or provided is unknown; however, the frequency undoubtedly depends on the definition used. Both quantitative and qualitative criteria for futility have been proposed, although consensus is lacking. In general, agreement is more easily achieved when situations are extreme, for example, when the patient is moribund.

At least in theory, identifying futility should transform decision-making and relieve families from considering treatments that cannot alter outcome, shifting the focus to those that can. Offering futile care makes little ethical sense: it cannot help, it may cause harm, and it may waste resources and deny other patients access to care.

Surrogate decision makers will occasionally request care that physicians consider futile. Professional societies have opined that physicians are not obligated to provide care that cannot achieve treatment goals, even if requested.5 Careful, informative, empathic discussions will generally resolve most disputes. In the minority that persist, a deliberate approach that incorporates second opinions and opportunities to transfer care may ultimately lead to unilateral decisions to forgo treatment. However, not all physicians agree that unilateral decisions are appropriate and some suggest deferring to families in the small minority where impasse cannot be resolved.4

For practical reasons, the futility rationale should probably be curtailed for all but the most obvious cases. Physicians and nurses are often unable to accurately identify futility, raising the possibility of error. Concerns about self-fulfilling prophecies suggest that poor outcomes may occur simply because physicians consider the prognosis poor. Finally, survival appears to be improving for some patients with traditionally devastating illnesses, such as stem cell transplant recipients with respiratory failure, suggesting that prior beliefs about futility may be obsolete. For these reasons, we believe futility designations should be limited to obvious cases, while favoring traditional approaches that balance risk, benefit, and patient preferences when there is doubt.

Unconstrained decision-making


Surrogate decision-making


Most decisions in the ICU are unconstrained by triage and futility concerns, leaving physicians and surrogates with options to consider. Respect for the patient’s autonomy should dictate most decisions. Unfortunately, most critically ill patients cannot represent themselves due to cognitive impairment resulting from their acute illness, delirium, sedation, or dementia. Surrogate decisions-makers, usually family members, must speak for them.6

Ideally, surrogates may be able to articulate patients’ previously documented wishes, for example if relevant advance directive are available. If no explicit direction is available, surrogates may be able to provide substituted judgment, indicating what they believe the patient would choose, for example, on the basis of prior discussions or what is known about the patient. If no information is available to guide these judgments, surrogates may be left to choose treatment they believe to be in the patient’s best interest.

Several factors are likely to increase the burden faced by surrogates. Decision-making subjects family members to enormous stress. Many family members experience severe anxiety and depression during the ICU stay, which could interfere with their ability to be effective surrogates.7 Some may not know the patient well enough to feel comfortable making decisions. Although they are probably more accurate than physicians, family members may not reliably make the same choices the patient would.2 Even if past discussions occurred, patients’ wishes may not be static – prior conversations and advance directives may not accurately portray what patients would choose under the circumstances encountered.

Certain observations may be helpful. The willingness of individual patients to endure aggressive therapy should not be underestimated. Many patients with severe underlying diseases are willing to choose aggressive ICU care, particularly if there is a chance for functional survival. In contrast, patients tend to be less willing to undergo ICU care if the likely outcome is functional or, especially, cognitive impairment.8

Family meetings


The primary purpose of family meetings is to choose treatments best suited to meet the patient’s goals. Effective family meetings can increase family satisfaction and may mitigate long term psychiatric complications during bereavement. At its core, appropriate family meetings include all the components of any other discussion devoted to informed decision making. Physicians must ensure that surrogates are in a position to make decisions most likely to meet the patient’s goals. Surrogates must have the capacity to make informed decisions and physicians must give them the information required, including descriptions of the patient’s illness, available treatments options, and the risks, benefits, and likely outcomes of each option. Most surrogates want physicians to contribute to decision-making9 and physicians should provide input to the degree that families desire.

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Jan 8, 2017 | Posted by in ANESTHESIA | Comments Off on Withholding and withdrawing life support in the intensive care unit

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