CHAPTER 58 URGENT FOLLOW UP FOR TIA: THE EXPRESS STUDY

Effect of Urgent Treatment of Transient Ischaemic Attack and Minor Stroke on Early Recurrent Stroke (EXPRESS Study): A Prospective Population-based Sequential Comparison

Rothwell PM, Giles MF, Chandratheva A, et al. Lancet. 2007;370(9596):1432–1442

BACKGROUND

The risk of recurrent stroke in the week after transient ischemic attack (TIA) is up to 10%. Multiple treatments are known to prevent stroke after TIA, including aspirin, antihypertensives, statins, anticoagulation for atrial fibrillation, and carotid endarterectomy. The ABCD study provided emergency clinicians with a risk stratification tool for stroke at 7 and 30 days, but there was a high degree of variation in the urgency with which preventive therapies were initiated after TIA. This varied from emergent inpatient management to routine nonurgent outpatient care. This study sought to quantify the suspected benefits of rapid treatment.

OBJECTIVES

To assess the effect of rapid treatment after TIA.

METHODS

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