Recent literature continues to refine which components of the early goal-directed therapy (EGDT) algorithm are necessary. Given it utilizes central venous pressure, continuous central venous oxygen saturation, routine blood transfusions, and inotropic medications, this algorithm can be timely, invasive, costly, and potentially harmful. New trials highlight early recognition, early fluid resuscitation, appropriate antibiotic treatment, source control, and the application of a multidisciplinary evidence-based approach as essential components of current sepsis management. This article discusses the landmark sepsis trials that have been published over the past several decades and offers recommendations on what should currently be considered ‘usual care’.
Key points
- •
Current sepsis trials have not shown a benefit from protocolized early goal-directed care, as opposed to usual care.
- •
Early recognition of sepsis, fluid resuscitation, appropriate antibiotic treatment, source control, and the application of multidiscipline evidence-based medicine are essential components of sepsis care.
- •
Central venous pressure and continuous central venous saturation measurements, placement of central venous catheters, and routine blood transfusions are not necessary for all patients with sepsis.
Related posts:
Severe Sepsis Care in the Emergency Department
An Introduction to the Most Complex Disease in Emergency Medicine
End Points of Sepsis Resuscitation
The Past, Present, and Future of the Centers for Medicare and Medicaid Services Quality Measure SEP-1
Source Identification and Source Control
Prehospital Sepsis Care
Stay updated, free articles. Join our Telegram channel
Full access? Get Clinical Tree
