The scope of pediatric regional anesthesia is expanding, with increased safety and efficacy data over the past few years. As familiarity and expertise has developed with ultrasonography, regional anesthesia has played an important role in the management of acute pain in the postsurgical population.
Key points
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Regional anesthesia is safe and effective in the pediatric population.
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Use of ultrasound guidance for peripheral nerve blocks is beneficial to be able to visualize needle advancement and local anesthetic deposition.
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For longer acting analgesia, continuous nerve catheters can be used.
Introduction
The use of regional anesthesia in the pediatric population has been increasing, especially with the introduction of ultrasound technology. There have been multiple reviews addressing the safety and complication rates in this population, as a large percentage of these regional blocks are performed after the induction of general anesthesia. Regional anesthesia is an important contributor of multimodal analgesia to improve patients’ health care experience and reduce hospital length of stays.
The Pediatric Regional Anesthesia Network (PRAN) database is a multicenter, collaborative registry looking specifically at the safety of regional nerve blocks performed at numerous children’s hospitals. The most recent analysis of these data includes a large data set, with more than 100,000 regional blocks, including both peripheral and neuraxial blocks. The investigators concluded that the use of regional blockade in children was safe, with minor catheter-related failures being the most common adverse events. There were no reported cases of permanent neurologic damage, and the rates of transient neurologic deficit and local anesthesia toxicity were low, at 2.4 and 0.76, respectively, per 10,000. In addition to the low incidence of complications, the use of ultrasound for regional anesthesia has allowed local anesthetic dosing to decrease. This is important in the neonatal and infant population and may increase effectiveness of blocks due to accurate localization.
This review discusses the use of regional anesthesia through ultrasound guidance in the pediatric population, and this includes indications, anatomy, ultrasound techniques, and complications of peripheral nerve blocks of the extremities and trunk based on the current pediatric literature.
Discussion
Upper Extremity Blocks
The brachial plexus can be blocked at several different locations to provide motor and sensory blocks for children undergoing surgical procedures of the upper extremity. Blockade of the brachial plexus can be completed at the axillary, interscalene, supraclavicular, and infraclavicular locations. The most common type of brachial plexus block performed is the supraclavicular block. With the increased use of ultrasound guidance, these blocks can be performed at any location safely and effectively. Regional anesthesia with the use of ultrasound guidance allows for better recognition of the anatomy of the brachial plexus and improved visualization of nearby structures during needle placement.
Axillary block
Indications, anatomy, and complications
The axillary block provides analgesia to the elbow, forearm, and hand. The terminal branches of the brachial plexus, the median, radial, and ulnar nerves, lie superficially in the axilla where they can be blocked as they surround the axillary artery. Although anatomic variations exist, the ulnar nerve is most commonly located anterior and inferior to the artery, and the radial nerve lies posteriorly. The median nerve is usually located superior and anterior to the axillary artery ( Fig. 1 ). An important consideration to successfully perform this block is the location of the musculocutaneous nerve, as it lies outside the axillary neurovascular sheath and therefore must be blocked separately from the other nerves. This nerve provides sensation to the posterior aspect of the forearm and is located between the biceps brachii and coracobrachialis muscles.
Ultrasound-guided axillary blocks in the pediatric literature are not well described, but the techniques used in adults can be applied. , With the ultrasound probe placed transverse to the humerus, an out-of-plane technique may be used. Circumferential spread of local anesthetic can be achieved with multiple injections while repositioning the needle, which must be done carefully, given the axillary sheath’s superficial depth. ,
Complications of an axillary block include infection, intravascular injection, hematoma, and nerve injury. With ultrasound guidance, the risk of accidental intravascular injection into the axillary artery is likely reduced.
Interscalene block
Indications, anatomy, and complications
The interscalene block provides analgesia to the shoulder and proximal humerus. This brachial plexus block is performed at the interscalene groove, where the trunks and roots lie posterior to the sternocleidomastoid muscle. The nerve roots, C5–C7, lie between the anterior and middle scalene muscles ( Fig. 2 ). The C8 and T1 dermatomes are often spared, so this block may not adequately cover more distal procedures of the arm.
This block can be performed under ultrasound guidance by placing the probe in the transverse oblique plane at the lateral edge of the sternocleidomastoid muscle, at the level of the cricoid cartilage. The interscalene groove, which is located deep to the sternocleidomastoid muscle and lateral to the subclavian artery, contains the neurovascular bundle of the C5, C6, and C7 nerve roots. The use of ultrasound to perform this block may decrease the volume of local anesthetic needed compared with using nerve stimulation.
Side effects associated with the interscalene block include hemidiaphragmatic paralysis, recurrent laryngeal nerve block, and Horner syndrome. , If larger volumes of local anesthetic are used, there are risks of contralateral, epidural, or intrathecal spread, leading to respiratory depression and possible loss of consciousness. The use of ultrasound may decrease the amount of local anesthetic needed for this block. , Despite concern for performing this block under general anesthesia due to risk of neurologic complications, a joint committee practice advisory from the European Society of Regional Anesthesia and Pain Therapy and the American Society of Regional Anesthesia and Pain Medicine stated that performing regional anesthesia in the pediatric population under general anesthesia or deep sedation was safe.
Supraclavicular block
Indications, anatomy, and complications
The supraclavicular block, which is performed at the level of the divisions, provides analgesia to the upper arm, elbow, and hand. The divisions of the brachial plexus are located superficial and lateral to the subclavian artery ( Fig. 3 ). All roots of the brachial plexus are blocked at this location. However, the suprascapular nerve, which innervates the shoulder joint, may be spared.
Under ultrasound guidance, the probe is placed in the coronal-oblique plane just superior to the upper border of the midclavicle. The subclavian artery lies adjacent to the brachial plexus and appears hypoechoic and pulsatile. In an in-plane approach, the needle is directed medially toward the brachial plexus, which lies lateral and superior to the subclavian artery. This approach decreases the risk of intraneural injection as well as the risk of vascular injury.
Complications of this block include intravascular injection, infection, hematoma, and pneumothorax. The risk of pneumothorax may be higher than other brachial plexus blocks due to the proximity of the apex of the lung, which lies just medial to the first rib. An in-plane approach with visualization of the entire needle while performing this block may help prevent this complication.
Infraclavicular block
Indications, anatomy, and complications
The infraclavicular block, similar to the supraclavicular block, is used for surgeries of the elbow, forearm, and hand. At this level, the cords of the brachial plexus are blocked. The cords are superficial to the axillary artery and veins and medial and inferior to the coracoid process ( Fig. 4 ). The pectoralis major and minor are located superficial to the brachial plexus. The medial cord can be difficult to visualize on ultrasound due to its location between the axillary artery and vein. This location is well suited for placement of brachial plexus catheters in children for prolonged analgesia. ,
In performing an ultrasound-guided infraclavicular block, the probe is placed inferior to the clavicle in a transverse orientation. The needle is directed laterally toward the cords and advanced using an out-of-plane technique. The local anesthetic is injected into the deep portion of the neurovascular sheath. Another technique, described by De José María and colleagues, places the probe parallel to the clavicle in a parasagittal plane, and the needle is directed toward the brachial plexus.
Complications related to infraclavicular blocks are similar to those of supraclavicular blocks. Vascular injury is also possible, given the proximity of the axillary artery and vein.
Lower Extremity Blocks
Femoral and saphenous nerve blocks
Indications, anatomy, and complications
The femoral nerve block is commonly used for surgeries of the knee. This block provides analgesia to the anterior thigh and knee and can be performed as a single-shot technique; a continuous catheter can be placed when longer-term pain relief is required. , The femoral nerve, originating from L2 to L4, is located deep to the fascia iliaca and lateral to the femoral artery and vein ( Fig. 5 ). On ultrasound, the neurovascular bundle is visualized with the probe placed in the inguinal crease. Given the risk of falls due to motor blockade, an alternative is to block the saphenous nerve, a branch of the femoral nerve, at the level of the adductor canal ( Fig. 6 ). The saphenous block can be performed proximally to provide sensory analgesia to the anterior knee or more distally to block sensation to the medial aspect of the lower leg.
For ultrasound-guided femoral nerve blocks, the probe is placed in the inguinal crease. The femoral artery is identified, and the nerve is visualized just lateral to the pulsating artery. The femoral vein should be visualized just medial to the artery. In contrast to the artery, it does not appear pulsatile and should be compressible. The needle should be placed at the lateral portion of the femoral nerve, using an in-plane or out-of-plane approach, with local anesthetic deposited to surround the nerve. , The saphenous nerve block is performed with the probe placed on the medial aspect of the thigh while the leg is abducted and laterally rotated. In an in-plane approach, the sartorius muscle is identified, and the needle is directed toward the saphenous nerve where local anesthetic is injected.
Complications for the femoral and saphenous nerve blocks include hematoma from vascular puncture, nerve injury, and infection.
Sciatic block
Indications, anatomy, and complications
The sciatic nerve is blocked via the subgluteal, popliteal fossa, or anterior approach in children. , The nerve roots of L4 to S3 comprise the sciatic nerve. This nerve provides sensation to the posterior thigh as well as the distal leg; the medial compartment receives innervation from the femoral nerve. The nerve courses and exits the pelvis through the greater sciatic foramen and then travels inferiorly to the gluteus maximus muscle ( Fig. 7 ). It divides into the tibial and common peroneal nerves around the posterior popliteal fossa ( Fig. 8 ). This block may be performed as a single-shot or continuous catheter technique in the pediatric population. ,