Obstetric Anesthesia

Analgesia for Labor: Obstetric Outcome and Economic Issues

β2-Adrenergic Receptor Genotype and Other Variables that Contribute to Labor Pain and Progress

Reitman E, Conell-Price J, Evansmith J, et al (Columbia Univ, NY) Anesthesiology 114:927-939, 2011^§

Abstract

Background

β2-Adrenergic receptor (β2AR) activity influences labor. Its genotype affects the incidence of preterm delivery. We determined the effect of β2AR genotype on term labor progress and maternal pain.

Methods

We prospectively enrolled 150 nulliparous parturients in the third trimester and obtained sensory thresholds, demographic information, and DNA. Cervical dilation, pain scores, and labor management data were extracted with associated times. The association of genetic and demographic factors with labor was tested using mixed effects models.

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