Childhood poisoning remains a common occurrence despite widespread educational efforts by healthcare providers and the utilization of childproof medication dispensers. The challenge to the pediatric intensivist can be daunting in determining which ingestions are potentially high risk and which are inconsequential. Yearly data collection reveals that more than 2 million exposures to toxic substances are reported to poison centers throughout the United States. The overwhelming majority of toxic exposures cause minimal to no effect; morbidity and mortality associated with these exposures are extremely uncommon (1). Poisoning that occurs in children less than 5 years of age is generally accidental and accounts for ~85%-90% of pediatric poisoning. Poisoning in a child older than 5 years is generally considered intentional and comprises the remaining 10%-15% of childhood poisonings (2). Unintentional overdoses may occasionally occur in teenagers who take alcohol and street drugs. Teenagers are also subject to hospitalization following suicide attempts or suicide gestures. The Toxic Exposure Surveillance System of the American Association of Poison Control Centers reports ingestion to be the primary route of exposure to toxic substances (1). Risk factors for childhood exposure include exploratory behavior, child abuse, the possibility of environmental exposures, suicide attempts in children, and neonates exposed to toxins in utero.