Physics of Ultrasound Imaging




Basics of Ultrasound



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Nature and Properties of Ultrasound Waves



Humans can hear sound waves with frequencies between 20 Hz and 20 KHz. Frequencies higher than this range are termed as ultrasound. A sound wave can be described as a mechanical, longitudinal wave comprised of cyclic compressions and rarefactions of molecules in a medium. This is in contrast to electromagnetic waves, which do not require a medium for propagation. The amplitude of these cyclic changes can be measured in any of three acoustic variables.1-3




  • Pressure: Routinely measured in pascals
  • Density: Units of mass per unit volume (eg, kg/cm3)
  • Distance: Units of length (eg, millimeters, centimeters)



Three parameters can be used to describe the absolute and relative strength (“loudness”) of a sound wave.




  • Amplitude: The amount of change in one of the above acoustic variables. Amplitude is equal to the difference between average and the maximum (or minimum) values of an acoustic variable (or half the “peak-to-peak” amplitude).
  • Power: The rate of energy transfer, expressed in watts (joules/second). Power is proportional to the square of the amplitude.
  • Intensity: The energy per unit cross-sectional area in a sound beam, expressed in watts per square centimeter (W/cm2). This is the parameter used most frequently when describing the biological safety of ultrasound (US).



The operator can modify all of the above parameters. Note that this is not the same as adjusting receiver gain, which is a postprocessing function.



Changes (usually in intensity) can also be expressed in a relative, logarithmic scale known as decibels (dB). In common practice, the lowest-intensity audible sound (10–12 W/cm2) is assigned the value of 0 dB. An increase of 3 dB represents a two-fold increase in intensity while an increase of 10 dB represents a ten-fold increase in intensity. This means that a sound with an intensity of 120 dB is one trillion times as intense as a sound of 0 dB.



Four additional parameters that are inherent to the sound generator (transducer) and/or the medium through which the sound propagates are also used. When referring to a single transducer (piezoelectric) element in a pulsed ultrasound system, these parameters cannot be manipulated by the operator.




  • Period: The duration of a single cycle. Typical values for clinical ultrasound are 0.1 to 0.5 microseconds (μs).
  • Frequency (f): The number of cycles per unit time. One cycle per second is 1 hertz (Hz). Ultrasound (US) is defined as a sound wave with a frequency greater than 20,000 Hz. Values that are relevant in clinical imaging modalities such as echocardiography and vascular ultrasound range from 2 to 15 megahertz (MHz).



Period and frequency are reciprocals. Period = 1/f.




  • Wavelength (λ): The distance traveled by sound in 1 cycle (0.1 to 0.8 mm)



Wavelength and frequency are inversely proportional, and are related by propagation speed through the formula λ = c/f.




  • Propagation speed (c): The speed of sound in a medium, determined by characteristics of the medium through which it propagates. Propagation speed does not depend on the amplitude or frequency of the sound wave. It is directly proportional to the stiffness and inversely proportional to the density of the medium.



Sound propagates at 1540 m/s for average human soft tissue, including heart muscle, blood, and valve tissue. Other useful values are 330 m/s for air and 4080 m/s for skull bone. Because the propagation speed in the heart is constant at 1540 m/s, the wavelength of any transducer frequency can be calculated as:



λ (mm) = 1.54/f (MHz)




Properties of Pulsed Ultrasound



Continuous waves are not useful for structural imaging. Instead, US systems use brief pulses of acoustic signal. These are emitted from the transducer during the “on” time and received during the “off” time. One pulse typically consists of 3 to 5 cycles.



Pulsed US can be described by 5 parameters (Figure 1–1):




  • Pulse duration: The time a pulse is “on”, which is very short (0.5 to 3 μs).
  • Pulse repetition period: The time from the start of a pulse to the start of the next pulse, and includes thelistening time. Typical values are 0.1 to 1 ms.
  • Spatial pulse length: The distance from the start to the end of a pulse (0.1 to 1 mm).
  • Duty factor: The percentage of time the transducer is actively transmitting US, usually 0.1% to 1%.




Figure 1-1.



Physical parameters describing continuous and pulsed ultrasound waves.




This means that the transducer element acts as a receiver over 99% of the time.




  • Pulse repetition frequency (PRF): The number of pulses that occur in 1 second, expressed in hertz (Hz). PRF is reciprocal to pulse repetition period. Typical values are 1000 to 10,000 Hz (not to be confused with the frequency of the US within a pulse, which is many times greater).



PRF is inversely proportional to imaging depth. Because sound takes time to propagate, a deeper image requires more listening time. Therefore, with a deeper image, the transducer can emit fewer pulses per second. This concept will also be important for the discussion of Doppler ultrasound.



The relation between the depth of a reflector and the time it takes for a US pulse to travel from the transducer to the reflector and back to the transducer (time-of-flight) is called the range equation:



Distance to Reflector (mm) = Propagation Speed (mm/μs) × Time-of-Flight (μs)/2



This allows the US systems to calculate the distance to a certain structure by measuring only the time-of-flight. Assuming that soft tissue has a uniform propagation speed of 1540 m/s, or 1.54 mm/μs, time-of-flight increases by 13 μs means for every 1 cm of depth of the reflector. This value is important for imaging and for Doppler US.




Propagation of Ultrasound Through Tissues



The most important effect of a medium on the US wave is attenuation, the gradual decrease in intensity (measured in dB) of a US wave. Attenuation results from three processes.




  • Absorption: Conversion of sound energy to heat energy.
  • Scattering: Diffuse spread of sound from a border with small irregularities.
  • Reflection: Return of sound to the transducer from a relatively smooth border between two media. It is reflection that is important for imaging.



Different tissues attenuate by different processes and at different rates.




  • Air bubbles reflect much of the US that engages them, and appear very echo dense (bright). Since sound attenuates the most in air, information distal to an air bubble is often lost as a result.
  • Lung, being mostly air filled, causes much scatter and results in the most attenuation of US by tissue.
  • Bone absorbs and reflects US, resulting in somewhat less attenuation than lung.
  • Soft tissue and blood attenuate even less than bone.
  • Water attenuates sound very little, mostly by absorption with very little reflection. It is therefore very echo lucent (appears black on image).



Within soft tissue, attenuation is proportional to both the US frequency and path length, and can be expressed by the following equation:



Attenuation (in dB) = 0.5 dB/(cm • MHz) × Path Length (in cm) × Frequency (in MHz)



Therefore, one may conclude that, high-frequency US has greater attenuation and poor penetration, and is less effective at imaging deeper structures.



Less than 1% of the incident US is usually reflected at the boundary between different soft tissues. The interfaces between air and tissue, and between bone and tissue are strong reflectors and can result in several types of artifacts (see Chapter 3).



As the US beam strikes a boundary between two media, three phenomena may occur:




  • Reflection can be further broken down into specular reflection and diffuse reflection or backscatter.
  • Transmission.
  • Refraction.



Reflection of the transmitted US signal from internal structures is the basis of US imaging. It can occur only if there is a difference in the acoustic impedance (measured in MRayls) between the 2 media, and is dependent on the angle of incidence of the US beam at the interface. Acoustic impedance is a property of the media, not of the US beam. It is directly proportional to both density and propagation speed of the material.



Specular reflectors have large, smooth surfaces, or have irregularities that are larger than the wavelength of the US beam. They are angle dependent, reflecting US best at normal incidence (90°, or perpendicular to the boundary).



Scatter reflectors (the “signal” used in US imaging) have irregularities that are about the same size or smaller than the wavelength of US that strikes the boundary. Scatter reflectors are also not angle dependent. A special type of scattering is termed Rayleigh scattering, and this occurs when US strikes an object much smaller than the beam’s wavelength (such as a red blood cell). Sound is scattered uniformly in all directions.



Refraction is a process associated with transmission and refers to the change of wave direction upon crossing the interface between two media. Refraction can occur only when the propagation speeds in the 2 media are different and the incident angle is oblique (Figure 1–2). Refraction is described by Snell’s law:



Sine (Refracted Angle)/Sine (Incident Angle) = Speed of Sound in Medium 2/Speed of Sound in Medium 1




Figure 1-2.



An illustration demonstrating refraction. In this example, the propagation speed of medium 1 is greater than medium 2, resulting in a lower transmission angle.




Thus, if the speed of sound in medium 2 is less than the speed of sound in medium 1, then the transmission (refracted) angle is less than the incident angle. Similarly, if the speed of sound in medium 2 is greater than the speed of sound in medium 1, then the transmission angle is greater than the incident angle.



Because it violates the assumption that US travels in a straight line, refraction may result in image artifacts (eg, second copy of a true reflector).


Dec 30, 2018 | Posted by in ANESTHESIA | Comments Off on Physics of Ultrasound Imaging

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