Opioid therapy in addicted patients: background and perspective from the UK



pain treatment except in modes of drug delivery. The desire for simple techniques for relieving pain has led doctors, particularly pain clinicians, to see opioids as a useful and valuable option and so there has been a drift to expand their use.

In the author’s own experience, in general, prescribing habits by pain specialists have had an “educational role” and are taken up by general practitioners, albeit a year or two later. However, in general, training in the management of chronic pain is still woefully inadequate.5–7 Furthermore, few doctors, including pain clinicians, develop a comprehensive practice in the area of chronic pain in the opioid-dependent patient, because they often find the legal, ethical, and practical problems overwhelming.

Opioid dependency – a misunderstood problem


Despite the increasing recognition of chronic pain and opioid use, there is still much misunderstanding in the minds of doctors and nurses over the terminology associated with opioid dependency. Doctors still often describe patients as being addicted to their analgesics when in reality they may have some degree of dependency, but are not engaged in patterns of behavior associated with addiction (Table 25.1). Conversely, people with dependency problems may develop acute or chronic pain, acute flare-ups of chronic pain, or pain associated with malignancy, AIDS or other life-limiting diseases. Furthermore, such patients may be taking their drugs for a variety of reasons (euphoria, escapism, relief of withdrawal symptoms, medicinal purposes, or a combination). The need for training in this area has been recognized and this is incorporated into the International Association for the Study of Pain (IASP) Curriculum.8 The reality is that there are large numbers of clinicians that are highly skilled in interventional pain practice, but the same is not true for treating pain in patients with dependency.

Key differences between the UK and the US


The organization of the Health Service is a major difference between the UK and the US. All patients have a general practitioner who is the key both to ongoing prescribing and to the access to secondary care. There is a very limited role for the hospital emergency department to act as a primary health clinic and the access to a supply of opioids at this point is minimal. In hospital practice there is usually good, regular communication with the general practitioner. The normal practice would be to agree that there should only be one prescribing point for the patient. Initially, the pain clinic may manage prescribing until optimum dosing is achieved before returning this to the general practitioner. Some pain services have also developed strong links with the local addiction services to manage the addict with pain problems by running joint clinics.

Hence, in the UK, there is very little ability to go from doctor to doctor to obtain more and more prescription drugs. In practice, patients occasionally “lose” their drugs or use an excess, although they quickly learn that their requests for replacement are rarely accepted. The ability for the well off and well connected to access such drugs from private practitioners is limited. Close oversight by regulators identifies aberrant and/or high cost prescribing of opioids prescribed in primary care in locality. Prescribing opiates for registered addicts is managed through the addiction services, in general. Therefore, the access to opiates is reasonably well controlled and GPs take part in the long-term management of patients using opiates for pain, often sharing care with the pain clinics and palliative care services.

Diversion of prescribed opioids does not appear to be a great problem in the UK. In the past, problems of diversion were well recognized with short-acting opioids such as Dipipanone (Diconal), Dextromoride (Palfium) and Pethidine (Meperidine). This was resolved by either the agreed local banning of the drugs, or by agreed tight restriction in prescribing. Furthermore, it is well recognized in primary care now through education that these drugs have no use for managing chronic pain. It is notable that, in the UK, the use of diamorphine (heroin) has never been discontinued, unlike most other countries. Its use is principally within hospital practice and in palliative care. There has neither been any evidence of a significant problem with diversion nor any contribution to the widespread problems of recreational heroin use. Some addicts have been prescribed pharmaceutical grade heroin regularly to manage their addiction and there is also open debate about the possibilities of this approach to reduce their health problems. For the addict then there would be little incentive to exchange a quality product for other street drugs.

In contrast, the mild opioid, Dextropropoxyphene, combined with Paracetamol is widely used and well tolerated by many patients. It has been withdrawn recently because of concerns over its potential lethal effect when taken in deliberate overdose. The withdrawal of the drug led to many patients suffering increased pain when they were unable to find a suitable alternative. The regulatory authorities however, did not appear to engage in any debate on the ethics of this with pain clinicians. There are many other aspects of modern life that are useful and safe, but dangerous in the hands of the irresponsible. The drug alcohol and the automobile are two good examples.


Professional guidelines


The clinician trying to treat the problem patient with opioid dependency will find little evidence from clinical trials to guide pain management. What information there is has been extensively reviewed but the advice and guidance available are based on opinion and consensus.9, 10 We are left in a situation where we are often faced with complex patients with complex problems and with limited resources and abilities to manage them. Trying to do the best for these patients is not determined by long-established medical and scientific principles. The American and British Pain Societies have however, produced guidelines giving practical advice.11, 12

The British Guidelines also give examples of specific patient problems and how to deal with them. However, most patients present with a number of interconnected issues that are not easily resolvable, as in our case examples. The objective of achieving good pain control, good coping skills, and compliant, limited drug use is usually unattainable. Therefore, compromise and pragmatism are often needed to contain unsolvable problems. If this is supported by the explicit use of ethical principles, it may be possible to find the optimum way forward.

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Jan 8, 2017 | Posted by in ANESTHESIA | Comments Off on Opioid therapy in addicted patients: background and perspective from the UK

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