CHAPTER 75 LOW TIDAL VOLUME VENTILATION IN ARDS

Ventilation With Lower Tidal Volumes as Compared With Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome

The Acute Respiratory Distress Syndrome Network. N Engl J Med. 2000;342(18):1301–1308

BACKGROUND

Acute lung injury and acute respiratory distress syndrome (ARDS) have high associated mortality. At the time of this study, it was posited that ventilation strategies using high tidal volumes (10 to 15 cc/kg) could lead to lung distention that exacerbate lung injury and ARDS. It was thought that lower tidal volume ventilation could reduce lung injury but would result in respiratory acidosis, hypoxemia, and hypercarbia. At the time of the study, it was unknown whether a high tidal volume or low tidal volume ventilation strategy was superior in patients with ARDS and the risks of conventional ventilation had not been studied.

OBJECTIVES

To determine whether the use of a low tidal volume ventilation strategy could improve outcomes in patients with ARDS by comparing high vs. low tidal volume ventilation patients.

METHODS

Prospective, multicenter, randomized trial at 10 tertiary academic medical centers between March 1996 and March 1999.

Participants

Related posts:

Oral vs. IV Rehydration Spontaneous Ureteral Stone Passage Heparinizing Unstable Angina Amiodarone in Ventricular Fibrillation Bicarbonate Therapy in DKA CT Before Lumbar Puncture in Meningitis

Stay updated, free articles. Join our Telegram channel

Join