CHAPTER 67 KETOROLAC VS. IBUPROFEN IN MUSCULOSKELETAL PAIN

Intramuscular Ketorolac vs. Oral Ibuprofen in Acute Musculoskeletal Pain

Turturro MA, Paris PM, Seaberg DC. Ann Emerg Med. 1995;26(2):117–120

BACKGROUND

Ketorolac is the only parenteral (IV or IM) nonsteroidal anti-inflammatory (NSAID) and had been shown to provide similar relief when compared to one dose of selected opiates in nonemergent settings. Despite its benefit over opioids (including lack of respiratory depression, addiction potential, and sedation), it was unclear if there was any benefit over traditional oral NSAIDs such as ibuprofen for musculoskeletal pain. Traditional NSAIDs are significantly less costly than ketorolac.

OBJECTIVES

To compare the efficacy of oral ibuprofen to that of IM ketorolac in acute musculoskeletal pain in the ED.

METHODS

Randomized, prospective, double-blind, single-center trial in US ED.

Patients

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