CHAPTER 14 HISTAMINE ANTAGONISTS IN ACUTE ALLERGIC REACTION

Improved Outcomes in Patients with Acute Allergic Syndromes who are Treated with Combined H1 and H2 Antagonists

Lin RY, Curry A, Pesola GR, et al. Ann Emerg Med. 2000;36(5):462–468

BACKGROUND

H₂-receptor antagonists were introduced as antacid medications in the late 1970s. Physicians started using H₂-blockers to treat allergic reactions, based on the theoretical benefit of increased histamine blockade. Prior to this study, there had been evaluation of H₂ blockade in preventing allergic reactions, but only one study had examined outcomes in treating patients with acute allergic reaction.

OBJECTIVES

To determine whether combined therapy with H₁ and H₂ antihistamines results in improved outcomes in patients with acute allergic symptoms.

METHODS

Randomized, double-blind, placebo-controlled trial conducted in a single urban academic ED between 1998 and 1999.

Patients

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