(1)
Royal Free NHS Foundation Trust, London, UK
Secondary dysmenorrhea is associated with underlying pelvic pathology and can lead to ED attendance.
Causes of secondary dysmenorrhoea
Lower genital tract:
Painful cryptomenorrhoea:
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Imperforate hymen
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Transverse vaginal septum
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Congenital absence of cervix
Acquired cervical stenosis
Uterus:
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Congenital uterine abnormalities: non-communicating horn
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Adenomyosis
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Pedunculatedsubmucous fibroid
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Endometrial polp
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Intrauterine adhesions
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Intrauterine device use
Pelvis:
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Endometriosis (may be associated with dysmenorrhoea, dyschezia, chronic pelvic pain, infertility, haematuria, and rectal bleeding)
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Chronic pelvic inflammatory disease
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Pelvic adhesions
Key historical features in secondary dysmenorrhoea
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Typically, the onset is after several years of painless periods
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The pain may not respond to non-steroidal anti-inflammatory agents or oral contraception
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Gynaecological symptoms: dyspareunia; abnormal vaginal discharge; menorrhagia; inter-menstrual or post-coital bleeding
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Gastrointestinal symptoms: rectal pain and bleeding (endometriosis)
Causes of abnormal vaginal bleeding
Abnormal menstrual bleeding:
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Excessive
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Reduced
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Inappropriate (by age)
Non-menstrual bleeding:
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Post-coital
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Intermenstrual
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Postmenopausal
Categories of excessive vaginal bleeding
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Menorrhagia: excessive menses (>80 ml monthly menstrual loss, ie >90th centile for menstrual blood loss) but normal cycle (>7 days with one or more days of excessive loss)
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Short cycle (<21/7) but normal menses (polymenorrhoea)
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Short cycle + excess bleeding (polymenorrhagia)
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Excessive menses at long intervals
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Metrorrhagia: irregular intervals with excessive menses
Causes of abnormal genital tract bleeding in the reproductive age group
Pregnancy –related
Early pregnancy
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Implantation bleeding
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Pregnancy failure: miscarriage (haemodynamic status; state of internal os; products of conception)
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Ectopic pregnancy
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Gestational trophoblastic disease (molar pregnancy)
Later pregnancy (antepartum haemorrhage-from 24 weeks of pregnancy)
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Placenta praevia: painless bleeding; soft, non-tender uterus; high presenting part or malpresentation
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Placental abruption: severe abdominal or back pain; uterine contractions may be present; uterine tenderness
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Vasa praevia
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Uterine inversion
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Retained placenta
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Endometritis
Non-pregnancy-related
Dysfunctional uterine bleeding: anovulatory bleeding; corpus luteum dysfunction.
Structural abnormalities
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Genital tract neoplasia: cervix; endometrium; vulva; vagina; Fallopian tube
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Polyps: cervix; endometrium
Infection:
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Endometritis
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Atrophic endometritis (post-menopausal)
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Cervicitis
Endocrine dysfunction:
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Hypothalamus/pituitary
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Adrenal
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Thyroid
Foreign bodies
Iatrogenic:
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Intrauterine devices
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Hormonal treatment
Blood dyscrasias:
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Platelet disorders:idiopathic thrombocytopenic purpura
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Clotting factor abnormalities: von Willebrand disease
Symptoms accompanying menorrhagia that indicate significant pathology
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Malignancy: persistent inter-menstrual or post-coital bleeding; unexplained vulval lump or vulval bleeding due to ulceration
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Other structural disease: pelvic pain; pressure symptoms
Causes of premenarcheal genital tract bleeding
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Trauma
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Lower genital tract neoplasm: cervix; vagina
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Foreign body
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Exogenous oestrogen
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Sporadic gonadotrophin surge
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Precocious puberty or pseudopuberty
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Gastrointestinal bleeding
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Urinary tract bleeding
Causes of menorrhagia
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Dysfunctional uterine bleeding (60%)
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Other gynaecological causes (35%)
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Uterine/ovarian tumours
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Endometrial hyperplasis
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Endometriosis
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Pelvic inflammatory disease
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Intrauterine contraceptive device
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Endocrine and haematological causes (<5%)
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Thyroid disease: hypothyroidism; hyperthyroidism
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Platelet problems: thrombocytopenia
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Clotting abnormalities: haemophilia; von Willebrand disease; anticoagulation
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