Fluoroacetate, also known as compound 1080, sodium monofluoroacetate (SMFA), and sodium fluoroacetate, is one of the most toxic substances known. In the past, it was used primarily as a rodenticide by licensed pest control companies, but it largely has been removed from the US market because of its hazardous nature. Compound 1080 use is currently restricted to livestock protection collars designed to protect sheep and cattle from coyotes. Occasionally, unlicensed product may be encountered. It is also still used commonly in Australia and New Zealand for vertebrate pest control. It is a tasteless, odorless water-soluble white crystalline powder. Fluoroacetamide (compound 1081) is a similar compound with similar toxicity.

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   Mechanism of toxicity

   
   
   
   
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      Fluoroacetate is metabolized to the toxic compound fluorocitrate, which blocks cellular metabolism by inhibiting the aconitase enzyme within the Krebs cycle. Clinical effects of poisoning are delayed (from 30 minutes to several hours) until fluoroacetate is metabolized to fluorocitrate.

      
      
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      Pharmacokinetics.

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