Type 2 HIT results in a reduction of platelets by at least 50%. HIT is seen in approximately 3% to 5% of patients exposed to unfractionated heparin and 1% of those exposed to low-molecular-weight heparin. In heparin-naïve patients, the condition usually presents 5 days after the initiation of heparin therapy. In patients exposed to heparin within the prior 100 days, HIT may develop sooner, often within 24 hours of heparin initiation. Heparin of bovine origin is more likely than porcine heparin to cause HIT type 2. The development of HIT does not depend on the quantity or dose of exposure. HIT type 2 has been demonstrated in patients exposed to minute amounts of heparin as may be found in heparin flushes and heparin-coated catheters. Discontinuation of heparin does not eliminate the risk for complications. HIT-associated thrombosis may occur up to 4 to 6 weeks after the discontinuation of heparin.