Pharmacology. Cyproheptadine is a first-generation histamine1 (H1) blocker with nonspecific serotonin (5-HT) antagonism. The administration of cyproheptadine to patients with serotonin syndrome appears to antagonize excessive stimulation of 5-HT1A and 5-HT2 receptors, resulting in improvements in clinical symptoms (based on anecdotal case reports).

Indications. Cyproheptadine

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