Cyclic antidepressants remain a leading cause of poisoning-related fatalities among psychoactive medications.
Patients will frequently present with minimal signs and symptoms only to abruptly decompensate from life-threatening cardiovascular and central nervous system toxicity.
Cardiovascular toxicity (specifically refractory hypotension) is the leading cause of morbidity and mortality in cyclic antidepressant overdose.
Hypertonic sodium bicarbonate should be given in 1–2 mEq/kg boluses to reverse the wide-complex dysrhythmias commonly encountered with cyclic antidepressant poisoning.
Cyclic antidepressants (CA) consist of a group of pharmacologically related medications that were initially developed in the late 1950s for the treatment of patients with severe depression. Although used less frequently for this purpose, their role has expanded to include the management of various alternative conditions including neuralgic pain, migraine headaches, enuresis, and attention deficit hyperactivity disorder. Traditional cyclic antidepressants have a chemical structure built on a 3-ring nucleus and include such medications such as amitriptyline, nortriptyline, doxepin, imipramine, and clomipramine. Antidepressants have historically remained a leading cause of pharmacologic self-poisoning owing to their near ubiquitous availability to a depressed patient population inherently at risk for self-harming behavior. Although the introduction of selective serotonin reuptake inhibitors (SSRIs) has decreased the overall incidence of CA poisonings, CA overdoses continue to account for a greater morbidity and mortality given their increased potential for significant toxicologic complications, especially in pediatric patients.
Cyclic antidepressants are nonselective agents that exhibit a wide array of pharmacologic effects with considerable variations in potency. The majority of clinical findings associated with CA poisoning can be attributed to ≥1 of the following pharmacologic actions:
Competitive inhibition of acetylcholine at central and peripheral muscarinic (but not nicotinic) receptors
Inhibition of α-adrenergic receptors
Inhibition of norepinephrine and serotonin uptake
Sodium channel blockade
Antagonism of GABA-A receptors
Although it is the inhibition of norepinephrine and serotonin uptake that is believed to account for the antidepressant effects of these agents, the alternative actions just listed account for the significant toxicity associated with CA overdose, with sodium channel blockade being the most important factor contributing to patient mortality.
Patients commonly present to the emergency department with minimal clinical findings only to develop life-threatening cardiovascular and central nervous system (CNS) manifestations within the timespan of a few hours. Co-ingestants are not uncommon in patients with CA overdoses, and this possibility must always be investigated.
Attempt to determine the exact amount of drug ingested, as the cyclic antidepressants have a rather narrow therapeutic window, and small excursions beyond the usual therapeutic range (2–4 mg/kg) may result in significant toxicity. Acute ingestions of more than 10–20 mg/kg will cause significant cardiovascular and CNS disturbances owing to the blockade of cardiac sodium channels and inhibition of CNS GABA-A receptors, respectively. Toxicity in children has been reported with ingestions as low as 5 mg/kg.
The clinical presentation of CA toxicity varies widely from mild anti-muscarinic signs and symptoms to severe cardiotoxicity, coma, and death (Table 60-1). Anti-muscarinic findings are commonly appreciated in poisoned patients, including dry skin and mucous membranes, diminished or absent bowel sounds, urinary retention, and sinus tachycardia. Acute cardiovascular toxicity must be recognized and treated expediently. Sinus tachycardia is a very common early finding, but typically does not result in hemodynamic compromise. That said, severe poisonings frequently progress to induce wide complex tachycardias and refractory hypotension. CNS toxicity can range from disorientation and agitation to outright lethargy. Early subtle alterations in levels of consciousness can quickly progress to obtundation and coma. Generalized tonic-clonic seizures occur in ~4% of all patients who present with CA poisoning and in 13% of those who subsequently experience cardiopulmonary arrest.
Clinical manifestations of toxicity resulting from cyclic antidepressants.
Cardiovascular Toxicity |
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Central Nervous System Toxicity |
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Anticholinergic Toxicity |
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Pulmonary Toxicity |
Acute lung-injury aspiration |