Pain Management

Chronic Pain Management

Randomized controlled trial of percutaneous vertebroplasty versus optimal medical management for the relief of pain and disability in acute osteoporotic vertebral compression fractures

Farrokhi MR, Alibai E, Maghami Z (Shiraz Univ of Med Sciences, Iran) J Neurosurg Spine 14:561-569, 2011^§

Abstract

Object

Osteoporotic vertebral compression fractures (VCFs) are a major cause of increased morbidity in older patients. This randomized controlled trial compared the efficacy of percutaneous vertebroplasty (PV) versus optimal medical therapy (OMT) in controlling pain and improving the quality of life (QOL) in patients with VCFs. Efficacy was measured as the incidence of new vertebral fractures after PV, restoration of vertebral body height (VBH), and correction of deformity.

Methods

Of 105 patients with acute osteoporotic VCFs, 82 were eligible for participation: 40 patients underwent PV and 42 received OMT. Primary outcomes were control of pain and improvement in QOL before treatment, and these were measured at 1 week and at 2, 6, 12, 24, and 36 months after the beginning of the treatment. Radiological evaluation to measure VBH and sagittal index was performed before and after treatment in both groups and after 36 months of follow-up.

Results

The authors found a statistically significant improvement in pain in the PV group compared with the OMT group at 1 week (difference −3.1, 95% CI −3.72 to −2.28; p < 0.001). The QOL improved significantly in the PV group (difference −14, 95% CI −15 to −12.82; p < 0.028). One week after PV, the average VBH restoration was 8 mm and the correction of deformity was 8°. The incidence of new fractures in the OMT group (13.3%) was higher than in the PV group (2.2%; p < 0.01).

Only gold members can continue reading. Log In or Register to continue

Share this:

• Click to share on Twitter (Opens in new window)
• Click to share on Facebook (Opens in new window)

Related

Related posts:

of change in daily step count over five years with insulin sensitivity and adiposity: population based cohort study of Cancer: The Next Generation Beverages and Risk of Metabolic Syndrome and Type 2 Diabetes: A meta-analysis time and haemodynamic response after thiopental vs. propofol in the elderly: a randomized trial monitoring of neuromuscular block over the orbicularis oris muscle in anesthetized patients receiving vecuronium Is Better Than General Anesthesia During Endovascular Acute Stroke Interventions

Stay updated, free articles. Join our Telegram channel

Join